Results 71 to 80 of about 12,782 (273)

Coupled Coincidence And Common Fixed Point Theorems For Mappings In Partially Ordered Metric Spaces [PDF]

, 2015
In this paper, we prove coupled coincidence points and common fixed points theorem for two mappings satisfying various contractive conditions in partially ordered metric spaces.
Arab, R., Godarzian, A.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Coupled fixed point theorems in complete metric spaces endowed with a directed graph and application

Open Mathematics, 2017
The purpose of this paper is to present some existence results for coupled fixed point of a (φ,ψ) —contractive condition for mixed monotone operators in metric spaces endowed with a directed graph.
Kir Mehmet, Yolacan Esra, Kiziltunc Hukmi   +2 more
doaj   +1 more source

Coupled Coincidence Fixed Point Theorems in S-Metric Spaces

IOSR Journal of Mathematics, 2014
In this paper we prove some coupled fixed point theorems in S-metric spaces.
Hans Raj, Nawneet Hooda
openaire   +1 more source

Coupled coincidence point results for (ψ,φ) -weakly contractive mappings in partially ordered Gb-metric spaces [PDF]

, 2013
In this paper we present some coupled coincidence point results for (ψ,φ) -weakly contractive mappings in the setup of partially ordered Gb -metric spaces. Our results extend the results of Cho et al. (Fixed Point Theory Appl.
Parvaneh, Vahid, Mustafa, Zead, Roshan, Jamal Rezaei, Abbas, Mujahid   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Generalized compatibility in partially ordered metric spaces [PDF]

Surveys in Mathematics and its Applications, 2016
In this paper, we introduce the notion of generalized compatibility of a pair of mappings F,G:X× X→ X, where (X,d) is a partially ordered metric space.
Hassen Aydi, Manel Jellali
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source