Results 41 to 50 of about 12,408 (253)

Tripled Coincidence and Common Fixed Point Results for Two Pairs of Hybrid Mappings

Abstract and Applied Analysis, 2014
The tripled fixed point is a generalization of the well-known concept of “coupled fixed point.” In this paper, tripled coincidence and common fixed point results for two hybrid pairs consisting of multivalued and single valued mappings on a metric ...
Marwan Amin Kutbi, Jamshaid Ahmad, Mujahid Abbas, Muhammad Arshad   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Some strong coupled coincidence and coupled best proximity results on complete metric spaces

Journal of Inequalities and Applications
In this paper, the concept of Wardowski’s class of contraction is integrated with that of g-coupling to define some F-contractive type g-couplings. We establish existence results for a coupled coincidence point, a strong coupled coincidence point, and a ...
Dakjum Eshi, Bipan Hazarika, Nipen Saikia, Sarah Aljohani, Sumati Kumari Panda, Ahmad Aloqaily, Nabil Mlaiki   +6 more
doaj   +1 more source

A Generalized Neutrosophic Metric Space and Coupled Coincidence Point Results

, 2021
This work introduces the notion of J-Neutrosophic Metric Space using the concept of Neutrosophic Sets. We analyze and extend some coupled coincidence point results on θJN -coupled and compatible mappings G : A × A → A and h : A → A where G has the mixed h-monotone property. We support the proposed result with suitable example.
Jeyaraman Mathuraiveeran, Suganthi Mookiah   +1 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Coupled Coincidence Point Results for (ψ,α,β)-Weak Contractions in Partially Ordered Metric Spaces

Journal of Applied Mathematics, 2012
In this paper coupled coincidence points of mappings satisfying a nonlinear contractive condition in the framework of partially ordered metric spaces are obtained. Our results extend the results of Harjani et al. (2011).
A. Razani, V. Parvaneh
doaj   +1 more source

Contributions to the coupled coincidence point problem in b-metric spaces with applications

Filomat, 2017
The aim of this paper is to present, in the context of b-metric spaces, coupled coincidence point theorems under some contraction type conditions. The method is based on the application of some coincidence point theorems of Ran-Reurings type in ordered b-metric spaces. Some applications will illustrate the theory.
Petruşel, Adrian, Petruşel, Gabriela, Yao, Jen-Chih   +2 more
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source