Results 101 to 110 of about 11,512,847 (280)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Unique Coupled Common Fixed Point Theorem for Symmetric (φ,ψ)-Contractive Mappings in Ordered G-Metric Spaces with Applications

Journal of Applied Mathematics, 2013
We establish the existence and uniqueness of coupled common fixed point for symmetric (φ,ψ)-contractive mappings in the framework of ordered G-metric spaces.
Manish Jain, Kenan Taş
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A common fixed point for weak øcontractions on b-metric spaces

, 2012
In this paper, we give a common fixed point result for single-valued and multi-valued mappings satisfying a weak Øcontraction in b-metric spaces. Presented theorems extend, generalize and improve some existing results in the literature. Some examples are
Aydi,H., Moradi,S., Bota,M.-F., Karapinar,E.   +3 more
core   +1 more source

Some Common Fixed Point Theorems in Menger Spaces [PDF]

, 2011
summary:In this paper, we prove some common fixed point theorems for occasionally weakly compatible mappings in Menger spaces. An example is also given to illustrate the main result. As applications to our results, we obtain the corresponding fixed point
Chauhan, Sunny, Pant, B. D., M. Tanveer, D. Mihet, Javid Ali, M. Imdad   +5 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Coupled Fixed Point Technique for Solving Coupled Systems of Functional and Nonlinear Integral Equations

Mathematics, 2019
In this paper, we obtain coupled fixed point results for F-contraction mapping satisfying a nonlinear contraction condition in the framework of complete metric space without and with a directed graph. As applications of our results, we study a problem of
Hasanen Abuelmagd Hammad, Manuel De la Sen   +1 more
doaj   +1 more source

Coupled Coincidence and Coupled Common Fixed Points of (ψ, ϕ) Contraction Type T-coupling in Metric Spaces

Iranian Journal of Mathematical Sciences and Informatics
Summary: In this paper, we define \((\psi, \phi)\)-contraction Type \(T\)-coupling, establish a theorem satisfying such contraction condition, and prove the existence and uniqueness of coupled coincidence and coupled common fixed points in metric space.
Abdulkerim, Fuad, Koyas, Kidane, Gebregiorgis, Solomon   +2 more
openaire   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source