Results 211 to 220 of about 354,099 (256)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Performance of Diffusion Monte Carlo Calculations for Predicting the Relative Energies of Quinoidal and Nonquinoidal Species. [PDF]

J Phys Chem Lett
Mauger N, Benali A, Jordan KD.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Double Transition in Left Bundle Branch Area Pacing. [PDF]

J Arrhythm
Mondal S, Muslim NA.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

GW Approximation Coupled with Classical Fluctuating Charges and Dipoles. [PDF]

J Chem Theory Comput
Nottoli G, Lafiosca P, Quintela Rodríguez FE, Egidi F, Förster A, Cappelli C.   +5 more
europepmc   +1 more source

The three-dimensional structure of a proton-pumping pathway, the H-pathway, is evolutionarily conserved in all three families of cytochrome <i>c</i> oxidase. [PDF]

Front Chem
Shimada A, Tsukihara T, Yoshikawa S.
europepmc   +1 more source

Robust chirality-induced spin selectivity in topologically chiral molecular knots. [PDF]

Nat Commun
Sun X, Zhang KY, Zhou SZ, Fu HH.
europepmc   +1 more source

Research on active collision avoidance control technology for intelligent connected monorail transit trains in the virtual coupling environment. [PDF]

PLoS One
Hou Z, Liang H, Yang G, Han J.
europepmc   +1 more source

Numerical simulation study of the effect of coal dust on gas explosion overpressure. [PDF]

Sci Rep
Fang Y, Mei J, Zhang H, Cheng D.
europepmc   +1 more source