Results 221 to 230 of about 1,550,218 (322)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Existence and controllability analysis of multi-term fractional coupled systems with generalized [Formula: see text]-Caputo-Fabrizio operators. [PDF]

Sci Rep
Saad KM, Abdo MS, Hamanah WM.
europepmc   +1 more source

On Common Coupled Fixed Point Theorems for Comparable Mappings in Ordered Partially Metric Spaces [PDF]

, 2014
Ali Mutlu, Nermin Yolcu, Berrin Mutlu, Necdet Bıldık   +3 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Thermal-mechanical coupling failure analysis and optimization of an exhaust manifold. [PDF]

MethodsX
Haiqiang L, Hao Z, Jian S.
europepmc   +1 more source

COUPLED FIXED POINT THEOREMS FOR MIXED G-MONOTONE MAPPINGS IN PARTIALLY ORDERED METRIC SPACES VIA NEW FUNCTIONS

, 2016
Müzeyyen Sangurlu, Arslan Hojat Ansari, Duran Türkoğlu   +2 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Multiharmonic Algorithms for Contrast-Enhanced Ultrasound. [PDF]

J Sci Comput
Nikolić V, Rauscher T.
europepmc   +1 more source

Coupled coincidence and common fixed point theorems for hybrid pair of mappings [PDF]

, 2012
Mujahid Abbas, Łjubomir Ćirić, Boško Damjanović, M. Ali Khan   +3 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source