In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim+11 more
wiley +1 more source
Nonminimal coupling, quantum scalar field stress-energy tensor and energy conditions on global anti-de Sitter space-time. [PDF]
Namasivayam S, Winstanley E.
europepmc +1 more source
Some new coupled fixed point theorems in partially ordered complete probabilistic metric spaces
Qiang Tu+3 more
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
wiley +1 more source
Nuclei discovered new practical insights via optimized soliton-like pulse analysis in a space fractional-time beta-derivatives equations. [PDF]
Fendzi-Donfack E+10 more
europepmc +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source
Novel closed-form travelling wave solutions for space-time fractional coupled Boussinesq-Burger model using extended direct algebraic method. [PDF]
Radwan T+4 more
europepmc +1 more source
Coupled Fixed Point Theorem for Mapping Satisfying Integral Type Contraction on Cone Metric Space
Surendra Kumar Tiwari+2 more
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