Results 61 to 70 of about 856,874 (305)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

open access: yesFEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr   +4 more
wiley   +1 more source

Coupled Potts models: Self-duality and fixed point structure [PDF]

open access: yesNuclear Physics B, 1999
70 pages; 17 tables and 15 figures in text.
Dotsenko, Vladimir   +3 more
openaire   +4 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

On Some Coupled Quasi-fixed Points Theorems

open access: yesJournal of Mathematical Analysis and Applications, 1996
AbstractSome existence theorems are known for coupled quasi-fixed points of nonlinear mixed monotone operators from ak-fold conical segment [u0,v0] into a real Banach space, wherek=1 or 2. In this note, we extend those results to an arbitrary but finitekby a simple but nontrivial iterative mechanism.
openaire   +2 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

New Existence Results and Generalizations for Coincidence Points and Fixed Points without Global Completeness

open access: yesAbstract and Applied Analysis, 2013
Some new existence theorems concerning approximate coincidence point property and approximate fixed point property for nonlinear maps in metric spaces without global completeness are established in this paper.
Wei-Shih Du
doaj   +1 more source

Weak Coupled Coincidence Point Results Having a Partially Ordering in Fuzzy Metric Spaces

open access: yesFuzzy Information and Engineering, 2016
Coupled coincidence and fixed point problems have been in the focus of the research interest for last few years. The problem was introduced in fuzzy metric spaces only very recently. In this paper, we work out a weak coupled coincidence point theorem for
P. Saha   +2 more
doaj   +1 more source

Some Rational Coupled Fuzzy Cone Contraction Theorems in Fuzzy Cone Metric Spaces with an Application

open access: yesJournal of Mathematics, 2021
In this paper, we establish the new concept of rational coupled fuzzy cone contraction mapping in fuzzy cone metric spaces and prove some unique rational-type coupled fixed-point theorems in the framework of fuzzy cone metric spaces by using “the ...
Saif Ur Rehman   +4 more
doaj   +1 more source

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