Results 161 to 170 of about 1,148,154 (395)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

open access: yesAdvanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann   +5 more
wiley   +1 more source

Gas side heat transfer [PDF]

open access: yes
Improvements in methods for predicting heat transfer rates on the hot gas side of turbine airfoils are necessary for improved turbine durability and performance.
Hylton, L. D.
core   +1 more source

Numerical investigation on vane leading edge impingement cooling performance under influences of ribs established between adjacent jets

open access: yesAdvances in Mechanical Engineering
Numerical studies on the vane leading edge jet impingement cooling are conducted to analyzed the influence of the cylindrical ribs applied between adjacent jets.
Junfei Zhou   +4 more
doaj   +1 more source

Assessing the Ecological Value: Monetizing Process Innovations in Tailored Forming

open access: yesAdvanced Engineering Materials, EarlyView.
This article introduces a method for evaluating the sustainability of innovations, even with limited data. The method is illustrated through an analysis of the “Tailored Forming” technology, which explores the impact of sustainability on economic value added.
Jonas Schneider   +4 more
wiley   +1 more source

Methods for heat transfer and temperature field analysis of the insulated diesel, phase 3 [PDF]

open access: yes
Work during Phase 3 of a program aimed at developing a comprehensive heat transfer and thermal analysis methodology for design analysis of insulated diesel engines is described.
Blumberg, Paul N.   +4 more
core   +1 more source

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