Results 111 to 120 of about 1,058,541 (295)
Ecosystem Health and SustainabilityUnderstanding the interaction patterns of coupled human and natural systems (CHANS) is essential for sustainable urban development. However, existing studies have often failed to categorize interaction patterns based on variations in CHANS, which may ...
Kaiping Wang +6 more
doaj +1 more source
Local institutions and Natural Resource Management [PDF]
As researchers and policy-makers confront the challenges of and opportunities for improving natural resource management, increasing attention is being given to the dynamics of coupled natural-human systems.
Bell, Kathleen P. +2 more
core +1 more source
The communication of meaning in social systems
, 2008 The sociological domain is different from the psychological one insofar as meaning can be communicated at the supra-individual level (Schutz, 1932; Luhmann, 1984). The computation of anticipatory systems enables us to distinguish between these domains in
Aoki +47 more
core +2 more sources
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Earth as a Hybrid Planet - The Anthropocene in an Evolutionary Astrobiological Context
, 2017 We develop a classification scheme for the evolutionary state of planets based on the non-equilibrium thermodynamics of their coupled systems, including the presence of a biosphere and the possibility of what we call an agency-dominated biosphere (i.e ...
Alberti, Marina +2 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Detection and attribution of climate change impacts in coupled natural-human systems in the Andes
Communications Earth & EnvironmentMountain regions are among the most sensitive and vulnerable to anthropogenic climate change. In this study, we systematically assess the observed impacts of climate change in the Andes and use expert review and model-based methods to identify the role ...
Ana Ochoa-Sánchez +5 more
doaj +1 more source
Integrated Assessment Models of Global Change [PDF]
Integrated Assessment Models of Global Change (IAM) are computer models which integrate sets of equations describing the interwoven evolution of the different sub-systems making up the Earth system:-human production systems and their economic ...
Pierre Matarasso
core
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source