Results 41 to 50 of about 267,842 (253)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Synthesis of human-nature feedbacks

Ecology and Society, 2015
In today’s globalized world, humans and nature are inextricably linked. The coupled human and natural systems (CHANS) framework provides a lens with which to understand such complex interactions.
Vanessa Hull, Mao-Ning Tuanmu, Jianguo Liu   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Who let the dog out? Dog owner attitudes and economics regulate the potential negative impact of domestic dogs on wildlife in a reserve network

Conservation Science and Practice
Many domestic animals have a profound impact on endangered species through complex interactions and spillover effects in and between coupled human and natural systems.
Yue Weng, William Joseph McShea, Hongbo Yang, Zhuojin Zhang, Weiming Lin, Fang Wang   +5 more
doaj   +1 more source

How urban impervious surface shapes bird foraging behavior in an arid city [PDF]

PeerJ
Wildlife behavior and interactions in urban ecosystems can vary across landscape types and species, with some birds dominating human-derived resources.
Simone Vega Rabelo, Jeffrey D. Haight, Heather L. Bateman   +2 more
doaj   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Conflict or Coordination? The Spatiotemporal Relationship Between Humans and Nature on the Qinghai‐Tibet Plateau

Earth's Future, 2023
As the Earth's Third Pole and the Asian water tower, the Qinghai‐Tibet Plateau (QTP) plays a key role in global climate regulation and biodiversity maintenance. Living in harmony with nature is vital for local and global sustainable development.
Haimeng Liu, Yi Cheng, Zhifeng Liu, Qirui Li, Haiyan Zhang, Wei Wei   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Practical Points for the Software Development of an Agent-Based Model of a Coupled Human-Natural System

IEEE Access, 2016
Modeling complex natural and human systems to support policy or management decision making is becoming increasingly common. The resulting models are often designed and implemented by researchers or domain experts with limited software engineering ...
Santiago L. Rovere, Michael J. North, Guillermo P. Podesta, Federico E. Bert   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source