Results 61 to 70 of about 267,842 (253)

A Practical Guide for Managing Interdisciplinary Teams: Lessons Learned from Coupled Natural and Human Systems Research

Social Sciences, 2020
Interdisciplinary team science is essential to address complex socio-environmental questions, but it also presents unique challenges. The scientific literature identifies best practices for high-level processes in team science, e.g., leadership and team ...
V. Reilly Henson, Kelly M. Cobourn, Kathleen C. Weathers, Cayelan C. Carey, Kaitlin J. Farrell, Jennifer L. Klug, Michael G. Sorice, Nicole K. Ward, Weizhe Weng   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

State-level variation drives wolf management in the northwestern United States

Environmental Research: Ecology
Recovered and recovering carnivore populations in Europe and North America can pose risks to some human livelihoods like livestock ranching. These risks can motivate wildlife managers to lethally remove carnivores—decisions that are often controversial ...
Leandra Merz, Nicolas T Bergmann, Casey L Brown, Jeff Vance Martin, Chloe B Wardropper, Jeremy T Bruskotter, Neil H Carter   +6 more
doaj   +1 more source

Reflooding the coupled human and natural system of the Waza-Logone Floodplain, Cameroon

Frontiers in Conservation Science
The rewilding framework is used to guide the restoration of ecological processes in natural systems, but the framework can also be used in the restoration of social and ecological processes in coupled human and natural systems.
Mark Moritz, Chelsea E. Hunter, Paul Scholte   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

From concept to practice to policy: modeling coupled natural and human systems in lake catchments

Ecosphere, 2018
Recent debate over the scope of the U.S. Clean Water Act underscores the need to develop a robust body of scientific work that defines the connectivity between freshwater systems and people.
Kelly M. Cobourn, Cayelan C. Carey, Kevin J. Boyle, Christopher Duffy, Hilary A. Dugan, Kaitlin J. Farrell, Leah Fitchett, Paul C. Hanson, Julia A. Hart, Virginia Reilly Henson, Amy L. Hetherington, Armen R. Kemanian, Lars G. Rudstam, Lele Shu, Patricia A. Soranno, Michael G. Sorice, Jemma Stachelek, Nicole K. Ward, Kathleen C. Weathers, Weizhe Weng, Yu Zhang   +20 more
doaj   +1 more source

Coupled human and natural systems: The evolution and applications of an integrated framework : This article belongs to Ambio's 50th Anniversary Collection. Theme: Anthropocene. [PDF]

Ambio, 2021
Liu J, Dietz T, Carpenter SR, Taylor WW, Alberti M, Deadman P, Redman C, Pell A, Folke C, Ouyang Z, Lubchenco J.   +10 more
europepmc   +1 more source