Results 121 to 130 of about 43,191 (254)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Compact 3-dB tapered multimode interference coupler in silicon-on-insulator
, 2001 We have fabricated a compact 3-dB multimode interference coupler with a large silicon-on-insulator cross section. To reduce the length of the usual symmetric interference multimode interference coupler, we propose using a parabolically tapered structure.
Wei HZ +4 more
core
Reliability Improved Design of the Coupler for Hybrid Bus Power-train
Kongzhi Yu Xinxi Jishu, 2016 It described the transmission chain structure and working modes of current hybrid bus,discussed the influence of start-lockout condition of the engine on the reliability of the coupler, analyzed the failure mechanism of such couplers in theory and ...
XI Like, LIU Ling, SONG Chao, SHI Wei
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
A novel quantum directional coupler based on Pi-shaped coupled electron waveguides
, 1996 We explore the possibility of a quantum directional coupler based on Pi-shaped coupled electron waveguides with smooth boundaries. By calculating the transmission spectra, we propose an optimized coupler structure with a high directivity and fine ...
Sheng WD +1 more
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
STS Coupler (J Box), CD Player, Pulse and Sound
This image reflects a view of the STS Coupler (J Box), CD Player, Pulse and Sound for the STS Self Teaching ...
core
, 2014 This video shows the microtubule-depolymerization dependent motions of a ring coupler. Although the plane of the ring oscillates slightly, it remains motionlessly on the microtubule wall until the shortening end comes by (thermal energy is not sufficient
McIntosh, J. Richard +3 more
core