Results 131 to 140 of about 43,191 (254)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Experimental Research on Running Safety of Heavy-load Locomotive under Longitudinal Force
机车电传动, 2017 To study the operation safety of heavy-load locomotive under effect of longitudinal force, by comparing the dynamic performance of different line conditions, different coupling force state and different coupler rotation angle, the relationship of ...
SHAO Jun, ZHANG Zhichao, YAO Xiaopei
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Temperature Dependence of Characteristics for Multimode Interference Based 3-dB Coupler in SOI
, 2003 The temperature dependence of characteristics for multimode interference (MMI) based 3-dB coupler in silicon-on-insulator is analyzed, which originates from the relatively high thermo-optic coefficient of silicon.
Liu Zhongli, Yan Qingfeng, Yu Jinzhong
core
Analysis and Disposal of Coupler Suspension Failure of High-speed and Heavy-duty Freight Locomotive
机车电传动, 2019 This paper researched on coupler suspension failure of high-speed and heavy-duty freight locomotive. The cause of the failure was researched systematically. The deviation of coupler height was the key point that caused the bumper floating.
Hongbo LIANG
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
机车电传动, 2013 For studying longitudinal force bearing capacity of slave locomotives in heavy haul trains, nonlinear draft gear models and detailed coupler models were developed after the analysis of working mechanism of 13A/QKX100 coupler/draft gear systems.
YANG Xiang-jian +3 more
doaj
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source