Results 71 to 80 of about 189,032 (295)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparison of the effectiveness of couple therapy methods in the theory of Choice, acceptance and commitment (ACT), and integrative couple therapy in marital commitment of couples

مجله علوم روانشناختی, 2019
Background: Marital commitment and its various dimensions are among the most important factors in the sustainability of a shared life. Much research has been done using paired therapeutic approaches of theory of choice, acceptance, and commitment, and ...
Maryam Sedghi, Azra Ghaffari, Reza Kazemi, Mohammad Narimani   +3 more
doaj  

Etiology and Management of Sexual Dysfunction [PDF]

, 2009
Sexual dysfunction is the impairment or disruption of any of the three phases of normal sexual functioning, including loss of libido, impairment of physiological arousal and loss, delay or alteration of orgasm.
Bevinahalli Nanjegowda, Raveesh, Muthugaduru Shivarudrappa, Narendra Kumar, Mysore Nagaraj, Anil Kumar, Pai, Nagesh Brahmavar, Rajagopal, Rajendra, Siddika, Nayeema   +5 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The effectiveness of compassion-focused couple therapy on positive and negative emotional expressiveness and intimacy expressiveness in incompatible couples [PDF]

مجله علوم روانشناختی
Background: A decrease in positive emotional expressiveness, a decrease in intimacy expressiveness, and an increase in negative emotional expressiveness are related to marital incompatibility.
Ali Derikvandi, Maryam Esfahaniasl
doaj  

The effect of systematic couple group therapy on families with depressed juveniles: a pilot trial

Frontiers in Psychiatry
BackgroundDepression is a primary cause of illness and disability among teenagers, and the incidence of depression and the number of untreated young people have increased in recent years. Effective intervention for those youths could decrease the disease
Tian-Jiao Meng, Ying Qian, Yu-Lu Wang, Bing-Ling Gao, Jia-Jia Liu, Jing-Li Yue, Deng-Hua Tang   +6 more
doaj   +1 more source

Research on humanistic-experiential psychotherapies [PDF]

, 2013
In this chapter we focus on research published since our previous reviews (Greenberg, Elliott & Lietaer, 1994; Elliott, Greenberg & Lietaer, 2004), which covered research published between 1978 and 2001, plus additional earlier research on humanistic ...
Elliott, Robert, Freire, Elizabeth, Greenberg, Leslie S., Timulak, Ladislav, Watson, Jeanne C.   +4 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Conjoint collaborative marital therapy: the effect of individual ego strengthening on outcome

Archives of Mental Health, 2014
Background: There are many techniques being followed in marital or couples therapy for the resolution of marital discord. In the particular module of Conjoint collaborative therapy where joint sessions with the couple run concurrently with individual ...
Anurag Srivastava
doaj