Results 91 to 100 of about 2,561,669 (294)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Reflexive audiencing practices for couple relationships-in-action [PDF]
, 2012 This doctoral study offers couples opportunities to be audiences to their own lives as a couple. It does this on the premise that a reflexive, recursive, process of acting and reviewing and acting enhances relationship possibilities.
Talbot, Wendy
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD. [PDF]
Front Psychiatry, 2021 Wagner AC +4 more
europepmc +1 more source
Socioculturally informed emotionally focused couples therapy: Impacts on biracial couples [PDF]
, 2023 This quantitative study aims to explore the efficacy of Emotionally Focused Couples Therapy (EFCT) for biracial couples using a randomized controlled trial with a control group and an experimental group. Each group will consist of 15 biracial couples who
Lai, Angie
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Stability and Nash implementation in matching markets with couples [PDF]
We consider two-sided matching markets with couples. First, we extend a result by Klaus and Klijn (2005, Theorem 3.3) and show that for any weakly responsive couples market there always exists a "double stable" matching, i.e., a matching that is stable ...
Claus-Jochen Haake, Bettina Klaus
core +2 more sources
A comparison of psychosocial adjustment among children of women who received behavioral couples therapy versus individually based therapy for substance use disorder. [PDF]
J Subst Abuse Treat, 2022 Schumm JA, O'Farrell TJ.
europepmc +1 more source