Results 111 to 120 of about 2,561,669 (294)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Why Do Couples Seek Marital Therapy?

, 2004
If therapists know why couples seek marital therapy, they can more effectively tailor their therapies to improve treatment outcome. Unfortunately, there have been no systematic studies to date on couples' reasons for seeking therapy.
Simpson, Lorelei E, Doss, Brian D, Christensen, Andrew   +2 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The path to couples therapy: A descriptive analysis on a Veteran sample. [PDF]

Couple Family Psychol, 2020
Jarnecke AM, Ridings LE, Teves JB, Petty K, Bhatia V, Libet J.   +5 more
europepmc   +1 more source

Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples

, 2011
Antiretroviral drugs have been shown to reduce risk of mother-to-child transmission of human immunodeficiency virus (HIV) and are also widely used for post-exposure prophylaxis for parenteral and sexual exposures.
Matthias Egger, Egger, Matthias, Rutherford, George W, Baggaley, Rachel C, Nandi Siegfried, Siegfried, Nandi, Anglemyer, Andrew, Andrew Anglemyer, Rachel C Baggaley, George W Rutherford   +9 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Psychotherapy with an adolescent girl in a mixed-race stepfamily in post-apartheid South Africa [PDF]

, 2011
Includes abstract.Includes bibliographical references.This thesis explored issues brought to therapy by a biracial stepfamily in post-apartheid South Africa.
Marks, Beulah
core   +1 more source

Group Versus Standard Behavioral Couples' Therapy for Alcohol Use Disorder Patients: Cost-Effectiveness. [PDF]

J Stud Alcohol Drugs, 2020
Dunlap LJ, O'Farrell TJ, Schumm JA, Orme SS, Murphy M, Murchowski PM.   +5 more
europepmc   +1 more source

Changes during the 1990's in the location of Swedish Power Couples: Consequences and Explanations [PDF]

Between 1990 and 1998 there was an increase by 4 percentage points of couples where both individuals were college educated, so-called power couples, in Swedish cities.
Isacsson, Gunnar, Regnér, Håkan
core