Results 71 to 80 of about 23,458,446 (299)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Research on the Spatial Structure of the Beijing–Tianjin–Hebei Urban Agglomeration Based on POI and Impervious Surface Coverage

Buildings
Exploring urban spatial structures through spatial coupling analysis methods is an important method to provide theoretical support for the construction of sustainable urban structures.
Tiange Zhang, Xia Zhu, Yuanping Liu, Cui Jia, Huimin Bai   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A study on the coupled effects of climate and built environment elements at urban block scale——A case study of Fengtai district in Beijing

Journal of Asian Architecture and Building Engineering
In recent years, rapid city development has significantly impacted the microclimate environments in urban blocks. Many studies have shown that varied built-up environmental factors lead to corresponding degrees of influence on microclimate.
Qi Zhang, Wenwen Gao, Xin Yang
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assembly Quality Control Technologies in Forced Clamping and Compensation Processes for Large and Integrated Aeronautical Composite Structures

Machines
For the new type of CFRP (Carbon Fiber Reinforced Plastic) thin-walled components with a large size and weak rigid structure, due to the integration of geometric features and the reduction in the amount of parts, the assembly size transmission chain is ...
Feiyan Guo, Qiangwei Bao, Jialiang Liu, Xiliang Sha   +3 more
doaj   +1 more source

Influences of Excitation on Dynamic Characteristics of Piezoelectric Micro-Jets

Micromachines, 2017
Piezoelectric micro-jets are based on piezoelectric ink-jet technology and can achieve the drop-on demand requirements. A piezoelectric micro-jet which is designed for bearing lubrication is presented in this paper.
Kai Li, Jun-Kao Liu, Wei-Shan Chen, Lu Zhang   +3 more
doaj   +1 more source

A genetic analysis of ambulatory cardiorespiratory coupling [PDF]

Psychophysiology, 2005
AbstractThis study assessed the heritability of ambulatory heart period, respiratory sinus arrhythmia (RSA), and respiration rate and tested the hypothesis that the well‐established correlation between these variables is determined by common genetic factors.
Kupper, H.M., Willemsen, G., Posthuma, D., de Boer, D., Boomsma, D.I., de Geus, E.J.C.   +5 more
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source