Results 91 to 100 of about 42,412 (298)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ecological IndicatorsTo achieve the objective of high-quality development, an in-depth examination of the coupling coordination relationship between industrial green water and science and technology (S&T) innovation is essential.
Fuhua Sun +4 more
doaj +1 more source
Evaluation of the Coupling and Coordination Degree of the Wellness Tourism Industry in Panxi Area
Advances in Social Development and Education ResearchThe party's 20th report points out that green and healthy development is an extremely important part of the China's modernization drive, an important guarantee for the sustainable development of the country, and a basic means to realize that "clear waters and green mountains are gold and silver mountains".
Zhenmei Zhu +4 more
openaire +1 more source
Differential contribution of coupling coordination degree of energy-economy-carbon emission system.
, 2022 Differential contribution of coupling coordination degree of energy-economy-carbon emission system.
Fengyuan Zhang (1424125) +2 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
High degree of coupling coordination of the two-level indicator combination during 2015−2019.
, 2023 High degree of coupling coordination of the two-level indicator combination during 2015−2019.
Yongzhen Wang (4631062) +1 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Coupling coordination degree of infrastructure and energy productivity: spatial analysis for China
Spatial Economic AnalysisUnder resource constraints, exploring the impact of infrastructure transformation on energy productivity (EP) holds significant importance. This study examines the impact of coupled coordination of infrastructure (CC) on EP using inter-provincial data from China and conducts a scenario analysis and cross-country comparisons.
Yuan Ma, Zi-ran Zhang, Yu-ling Yang
openaire +1 more source
Classification of the degree of coupling coordination.
Classification of the degree of coupling coordination.
Tong Zhang (103827) +2 more
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source