Results 71 to 80 of about 20,600,286 (298)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Spatio-temporal characteristics and coupling coordination relationship between industrial green water efficiency and science and technology innovation: A case study in China

Ecological Indicators
To achieve the objective of high-quality development, an in-depth examination of the coupling coordination relationship between industrial green water and science and technology (S&T) innovation is essential.
Fuhua Sun, Jiayi Guo, Xin Huang, Zelong Shang, Bu Jin   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Requirements of Parallel Combat System Based on GQFD-Coupling Coordination Degree

, 2023
: In view of future intelligent unmanned combat characteristics, the concept of parallel combat is proposed and the model of parallel combat system is built based on OODA ring theory.
Li, Liang, Si, Bingshan, Dong, Zhiming
core   +1 more source

Study on the Coupling between Ecological Protection and High-quality Economic Development in Northwest China

Guangdong nongye kexue, 2022
【Objective】The study was conducted to establish a comprehensive evaluation index system for ecological protection and high-quality economic development in Northwest China, and measure the coupling coordination level of the "ecology-economy" system in ...
Jin WANG, Ning LI
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Research on the coupling measurement of medical education and health resource allocation under the background of healthy China

BMC Medical Education
Objective To analyze the coupling and coordination level of medical education and health resource allocation in China, and to provide scientific basis for promoting the high-quality development of medical education and the efficient allocation of health ...
Chen Jieting, Zhu Yan, Song Zhilong, Li Siyuan, Wu Xiangwei   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Types of coupling coordination degree between scientific and technological innovation and ecological environment optimization.

, 2023
Types of coupling coordination degree between scientific and technological innovation and ecological environment optimization.
Yongzhen Wang (4631062), Xianzhong Cao (7512014)   +1 more
core   +1 more source