Results 81 to 90 of about 17,148,895 (288)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Spatio-Temporal Evolution and Influencing Factors of Supply–Demand Coupling and Coordination in Civil Aviation Passenger Transport

Applied Sciences
The interaction between supply and demand of civil aviation passenger transport serves as an important reference for airport planning, transportation structure optimization and dynamic matching of supply and demand. Based on the panel data of 31 province-
Yanling Yang, Minghua Hu, Jianan Yin, Wei Wu   +3 more
doaj   +1 more source

Study on the Coupling Development between Urbanization and Ecosystem-- The Comparative Analysis Based on Guizhou, Yunnan, Hunan and Zhejiang Province

MATEC Web of Conferences, 2017
Urbanization and ecological environment coordinated development is the development direction of contemporary urbanization. In this paper, the coupling degree model is used to analyze the coupling degree and coupling coordination degree of Guizhou, Yunnan,
Luo Lingyun, Li Chenggang, Hu Jue, Yang Bing, Pan Kang   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Coupling degree and coordination degree of urban agricultural informatization and agricultural economic development in Shandong Province.

, 2022
Coupling degree and coordination degree of urban agricultural informatization and agricultural economic development in Shandong Province.
Zhe Zhao (157204), Yu Sun (18463), Mingquan Li (9225594)   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Evaluating Urban Ecological Livability Based on the Coupling Coordination Degree Model: A Case Study of Guangzhou

E3S Web of Conferences
The construction of an ecologically livable city has emerged as a crucial objective in Guangzhou's “14th Five-Year Plan” and the vision for 2035. This paper establishes an evaluation index system for urban ecological livability, encompassing five dimensions: economy, society, technology, environment, and nature.
Huang Shan, Wang Baoqiang
openaire   +2 more sources