Results 91 to 100 of about 24,411 (292)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Analysis and identification of subsynchronous vibration for a high pressure parallel flow centrifugal compressor [PDF]
The summary of a complete analytical design evaluation of an existing parallel flow compressor is presented and a field vibration problem that manifested itself as a subsynchronous vibration that tracked at approximately 2/3 of compressor speed is ...
Donald, G. H. +3 more
core +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair
Advanced Science, EarlyView.This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar +9 more
wiley +1 more source
Vacuum–Laser Fabrication of Programmable Soft Actuators
Advanced Science, EarlyView.A rapid and accessible fabrication strategy for inflatable soft actuators is presented, combining vacuum sealing with laser cutting of low‐cost thermoplastic pouches. The method enables precise sealing, fast fabrication, and programmable multi‐cell geometries.
Ashkan Rezanejad +5 more
wiley +1 more source
Bio‐templated Piezoresistive Yarn for High Sensitivity Movement Monitoring Textiles
Advanced Science, EarlyView.This study developed a conductive coating by biotemplating silver nanoparticles (AgNPs) onto a Potato virus A (PV) particle network, cross‐linked on co‐polyamide‐starch (CoPA‐SS) coils. The combination of CoPA‐SS's shape memory and PV‐AgNP's piezoresistivity achieved high strain sensitivity and minimal hysteresis.
Swarnalok De +10 more
wiley +1 more source
Aerodynamic instability: A case history [PDF]
The identification, diagnosis, and final correction of complex machinery malfunctions typically require the correlation of many parameters such as mechanical construction, process influence, maintenance history, and vibration response characteristics ...
Eisenmann, R. C.
core +1 more source
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott +15 more
wiley +1 more source