Results 61 to 70 of about 2,979,826 (304)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Jixie chuandong, 2020 Sparse representation has a wide range of applications in the field of image processing and audio processing. Applying the sparse representation theory to the field of vibration signal processing can efficiently represent the periodic components of the ...
Xiaoyun Gong +3 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Novel Weighted Block Sparse DOA Estimation Based on Signal Subspace under Unknown Mutual Coupling
In this paper, a novel weighted block sparse method based on the signal subspace is proposed to realize the Direction-of-Arrival (DOA) estimation under unknown mutual coupling in the uniform linear array.
Yulong Liu +3 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Can we avoid high coupling? [PDF]
, 2011 It is considered good software design practice to organize source code into modules and to favour within-module connections (cohesion) over between-module connections (coupling), leading to the oft-repeated maxim "low coupling/high cohesion".
Taube-Schock, Craig +5 more
core +1 more source
The coupling of the M2 muscarinic receptor to its G protein is voltage dependent.
PLoS ONE, 2019 G protein coupled receptors (GPCRs) participate in the majority of signal transduction processes in the body. Specifically, the binding of an external agonist promotes coupling of the GPCR to its G protein and this, in turn, induces downstream signaling.
Yair Ben-Chaim +2 more
doaj +1 more source
CREB Couples Neurotrophin Signals to Survival Messages [PDF]
Neuron, 2000 There are several interacting pathways for survival, death, bcl-2 transcription, and CREB Ser-133 phosphorylation. Some of this richness is described below. For example, although CREB-dependent activation of bcl-2 transcription is an attractive mechanism to explain neurotrophin-induced survival, the contribution of this pathway to programmed cell death
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Wound Synchronous Machine Sensorless Control Based on Signal Injection into the Rotor Winding
Energies, 2018 A sensorless position scheme was developed for wound synchronous machines. The demodulation process is fundamentally the same as the conventional signal-injection method.
Jongwon Choi, Kwanghee Nam
doaj +1 more source