Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Accessible Technology Course Design Practices for Inclusivity in Nursing Education. [PDF]
Nurse EducKotcherlakota S +3 more
europepmc +1 more source
True Grit: Passion and persistence make an innovative course design work. [PDF]
PLoS Biol, 2019 Casper AM, Eddy SL, Freeman S.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Inquiry-Team-Based Lab Course Design Enhances Underrepresented Undergraduate Predictors of Persistence in the Sciences. [PDF]
Med Sci EducDenton NL, Kulesza AE.
europepmc +1 more source
Course Design for College Entrepreneurship Education - From Personal Trait Analysis to Operation in Practice. [PDF]
Front Psychol, 2019 Wu HT, Chen MY.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Building a Boot Camp: Pediatric Residency Preparatory Course Design Workshop and Tool Kit. [PDF]
MedEdPORTAL, 2019 Hartke A, Devon EP, Burns R, Rideout M.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Development and implementation of a high-fidelity simulation training course for medical and nursing collaboration based on the Fink integrated course design model. [PDF]
Front Med (Lausanne)Jiang MH +5 more
europepmc +1 more source