Results 191 to 200 of about 4,783,756 (301)

Flipped-learning course design and evaluation through student self-assessment in a predental science class. [PDF]

Korean J Med Educ, 2017
Ihm J, Choi H, Roh S.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Modification of a pharmacokinetics course design to improve student performance. [PDF]

Am J Pharm Educ, 2014
Hughes GJ, Cassagnol M, Wu W, Howland MA, Sym D, El-Chaar GM, Smith CJ.   +6 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Chatbot-assisted quantum chemistry for explicitly solvated molecules. [PDF]

Chem Sci
Gadde RSK, Devaguptam S, Ren F, Mittal R, Dong L, Wang Y, Liu F.   +6 more
europepmc   +1 more source

Is blended learning and problem-based learning course design suited to develop future public health leaders? An explorative European study. [PDF]

Public Health Rev, 2018
Könings KD, de Jong N, Lohrmann C, Sumskas L, Smith T, O'Connor SJ, Spanjers IAE, Van Merriënboer JJG, Czabanowska K.   +8 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Traditional Versus Online Biology Courses: Connecting Course Design and Student Learning in an Online Setting. [PDF]

J Microbiol Biol Educ, 2016
Biel R, Brame CJ.
europepmc   +1 more source

MULTI-DISCIPLINARY APPROACH TO EFL UNIVERSITY COURSE DESIGN: EXPERIENCE AND CHALLENGES [PDF]

, 2011
Zuyenok, Iryna
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source