Results 121 to 130 of about 4,509,075 (305)

A System Bioinformatics Approach Predicts the Molecular Mechanism Underlying the Course of Action of Radix Salviae Reverses GBM Effects. [PDF]

Evid Based Complement Alternat Med, 2021
Jiaojiao S, Yuping H, Yajuan L, Guangyi L, Qiuhong L, Shengbiao L, Hong Y.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Course Review Horay (CRH) Learning Model to Improve Mathematical Learning Outcomes of Integers Materials [PDF]

, 2019
One of the problems in the learning process of class V SD Al-Manar Surabaya in the academic year 2019-2020 integer material is the teacher uses lecture methods that make students quickly bored and passive. The impact is students have difficulty accepting
Abdillah, A. (Abdillah), Setiyawan, H. (Hery)   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The course of experimental staphylococcus infection in albino mice during action of certain factors of space flight [PDF]

A study was made of the effect of certain factors of space flight, acceleration and hypokinesia, on the course of experimental staphylococcus infection in mice.
Borman, E. A., Prokhorov, V. Y., Shilov, V. M.   +2 more
core   +1 more source

Authorware Academic and Authorware Professional, Part 2

Canadian Journal of Learning and Technology, 1990
Earl R. Misanchuk
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Authorware Professional: Part 1

Canadian Journal of Learning and Technology, 1990
Len Proctor
doaj   +1 more source

Les apports mutuels du Cours d’Action et de la Cognition Distribuée à la compréhension des interactions inter‑espèces : le cas d’une relation singulière écuyer‑sauteur

Activités
The aim of this article is to test the fruitfulness of bringing together two research programmes, Course of Action (PRCA) and Distributed Cognition (PRCD), for the study of human-animal interactions.
Marine Leblanc, Benoît Huet, Jacques Saury   +2 more
doaj   +1 more source