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Covalent modifications of aminophospholipids by 4-hydroxynonenal
Free Radical Biology and Medicine, 1998Lipid oxidation is implicated in a wide range of pathophysiological disorders, which leads to reactive compounds such as aldehydes. Among them 4-hydroxynonenal (4-HNE) reacts strongly with the NH2 groups of amino acids and forms mainly Michael adducts and minor Schiff-base adducts. Such reactions occur also with compounds containing thiol groups.
M, Guichardant +3 more
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Regulation by Covalent Modification
2009The preceding chapter showed that the regulation of enzymatic activity can be carried out through a variety of mechanisms. Regulation involving covalent processes is even more diverse. These processes include various co- and post-translational events such as limited proteolysis and various chemical modifications (glycosylation, carboxylation, ADP ...
Jeannine Yon-Kahn, Guy Hervé
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Posttranslational Covalent Modification of Proteins
Science, 1977A search for derivatized amino acids in proteins has shown that the extent of posttranslational modification of proteins is quite substantial. While only 20 primary amino acids are specified in the genetic code and are involved as monomer building blocks in the assembly of the polypeptide chain, about 140 amino acids and amino acid derivatives have ...
Rosa Uy, Finn Wold
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Advances of Covalent Chemical Modifications of RNA
Chemistry – A European JournalABSTRACT Chemical modification of RNA can endow RNA molecules with novel structures and functions, enabling broader clinical application potential. RNA chemical modification is a systematic and controllable engineering approach, particularly at the cellular or tissue level, requiring precise modification strategies to reduce off ...
Yong Li +7 more
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Covalent Modification of G Proteins by Affinity Labeling
2003The activation of heterotrimeric G-proteins is tightly regulated by the exchange of GTP for GDP in the alpha-subunit; mostly--but not exclusively--seven-transmembrane receptors function as the guanine nucleotide exchange factors (GEFs). A research goal may be to determine which G-protein alpha-subunit is activated by the receptor under investigation ...
Martin, Hohenegger +2 more
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Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013Multimeric globins (e.g., hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric globins (e.g., myoglobin; Mb) usually are assumed to be non-allosteric. However, the modulation of the functional properties of monomeric globins by non-covalent (or allosteric) and covalent modifications casts doubts on this general ...
Ascenzi, P +10 more
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Covalent modification and metabolic control analysis
European Journal of Biochemistry, 1990A study of the sensitivity properties of metabolic systems containing covalently modifiable enzymes and cascades has been carried out with the aid of metabolic control analysis. We have considered how the theorems of metabolic control analysis must be modified to take into account covalently modifiable enzymes, and have used these results to ...
J R, Small, D A, Fell
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Covalent modification of PTPases
1998Abstract The large, transmembrane PTPases have been shown in several cases to undergo proteolytic processing of a proprotein that produces protein subunits, including LAR, RPTP-k and RPTP-σ. The site and determinants of LAR proprotein cleavage have recently been evaluated [105, 110, 116].
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Enhancement of anticancer potential of polyphenols by covalent modifications
Biochemical Pharmacology, 2016As evidenced by a growing number of respective clinical trials, a promising and increasingly valued approach to cancer prevention is chemoprevention which is based on using synthetic, semisynthetic, or natural compounds with the aim of preventing, delaying, arresting, or reversing carcinogenesis.
Urszula, Lewandowska +2 more
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Inheritance of a covalent histone modification
Science, 2015Epigenetics Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that package the DNA. These marks can determine tissue- and organ-specific gene expression patterns, which must be transmitted to daughter cells
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