Results 1 to 10 of about 442 (142)

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]

Marine Drugs, 2020
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore, Roberto Gimmelli, Marco Persico   +2 more
exaly   +13 more sources

Evaluation of the Activity of the Sponge Metabolites Avarol and Avarone and their Synthetic Derivatives Against Fouling Micro- and Macroorganisms [PDF]

Molecules, 2007
The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3’-(p-chloro-phenyl)avarone
Claire Hellio, Irena T Novakovic, Srđan Tufegdžić   +2 more
exaly   +19 more sources

The kinetics of the reduction of the lipophilic quinone avarone by n-alkyl-1,4-dihydronicotinamides of various lipophilicities [PDF]

Journal of the Serbian Chemical Society, 1999
Several NADH model compounds, N-alkyl-1,4-dihydronicotinamides, some of them possessing amphiphilic properties, have been synthesized, and the kinetics of their reaction with a biologically active liphophilic quinone, avarone, has been studied in a ...
MIROSLAV J. GASIC, DUSAN SLADIC, MARIO ZLATOVIC   +2 more
doaj   +12 more sources

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara [PDF]

Pharmaceutics, 2023
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to ...
Marcello Casertano, Massimo Genovese, Alice Santi, Erica Pranzini, Francesco Balestri, Lucia Piazza, Antonella Del Corso, Sibel Avunduk, Concetta Imperatore, Marialuisa Menna, Paolo Paoli   +10 more
doaj   +2 more sources

Protein covalent modification of biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of β-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione ...
Sladić Dušan M., Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milić Dragan, Šolaja Bogdan A., Gašić Miroslav J.   +7 more
doaj   +5 more sources

Chemical modification of β-lactoglobulin by quinines [PDF]

Journal of the Serbian Chemical Society, 2003
The avarone/avarol quinone/hydroquinone couple, as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of β-lactoglobulin, isolated from cow milk, by avarone, its model compound 2-tert-butyl-1,4 ...
Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milosavić Nenad B., Sladić Dušan M.   +5 more
doaj   +5 more sources

Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone [PDF]

Journal of the Serbian Chemical Society, 2007
The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined.
IVANA PAJIC, ZORAN VUJCIC, MIROSLAVA VUJCIC, IRENA NOVAKOVIC, DUSAN SLADIC, MIROSLAV J. GASIC   +5 more
doaj   +6 more sources

The use of bones as tools in Late Lower Paleolithic of Central Italy [PDF]

Scientific Reports
The Latium area in Italy has yielded rich evidence of Lower Paleolithic sites with both faunal remains, artefacts, and human fossil remains, such as the Ceprano human skull. Many are the sites where lithic industry has been found in association with bone
Flavia Marinelli, Marie-Helénè Moncel, Cristina Lemorini   +2 more
doaj   +2 more sources

Cytotoxic Terpene Quinones from Marine Sponges [PDF]

Marine Drugs, 2010
The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities.
Marina Gordaliza
doaj   +2 more sources

Regioselectivity of conjugate additions to monoalkyl-1,4-benzoquinones [PDF]

Journal of the Serbian Chemical Society, 2002
The regioselectivity of the reaction of conjugate addition of thiols, amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl-1,4-benzoquinone was investigated.
SNEZANA TRIFUNOVIC, MIROSLAV J. GASIC, MARIO ZLATOVIC, IRENA NOVAKOVIC, DUSAN SLADIC, TATJANA BOZIC   +5 more
doaj   +3 more sources