Results 1 to 10 of about 272 (123)

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]

Marine Drugs, 2020
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Marcello Casertano, Concetta Imperatore, Nicoletta Basilico   +2 more
exaly   +10 more sources

Evaluation of the Activity of the Sponge Metabolites Avarol and Avarone and their Synthetic Derivatives Against Fouling Micro- and Macroorganisms [PDF]

Molecules, 2007
The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3’-(p-chloro-phenyl)avarone
Vassilios Roussis, Irena Novakovic, Dusan Sladić   +2 more
exaly   +12 more sources

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara [PDF]

Pharmaceutics, 2023
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to ...
Marcello Casertano, Massimo Genovese, Alice Santi, Erica Pranzini, Francesco Balestri, Lucia Piazza, Antonella Del Corso, Sibel Avunduk, Concetta Imperatore, Marialuisa Menna, Paolo Paoli   +10 more
doaj   +3 more sources

Bioconjugate of lysozyme and the antibacterial marine sesquiterpene quinone avarone and its derivatives. [PDF]

Bioconjug Chem, 2012
A conjugate of lysozyme with avarone, a bioactive sesquiterpene quinone of marine origin, and its three derivatives, was synthesized. MALDI TOF mass spectral analysis and tryptic digestion showed that the only residue in lysozyme that was modified by all
Novaković I, Anđelković U, Zlatović M, Gašić MJ, Sladić D.   +4 more
europepmc   +8 more sources

The use of bones as tools in Late Lower Paleolithic of Central Italy [PDF]

Scientific Reports
The Latium area in Italy has yielded rich evidence of Lower Paleolithic sites with both faunal remains, artefacts, and human fossil remains, such as the Ceprano human skull. Many are the sites where lithic industry has been found in association with bone
Flavia Marinelli, Marie-Helénè Moncel, Cristina Lemorini   +2 more
doaj   +3 more sources

Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone [PDF]

Journal of the Serbian Chemical Society, 2007
The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined.
IVANA PAJIC, ZORAN VUJCIC, MIROSLAVA VUJCIC, IRENA NOVAKOVIC, DUSAN SLADIC, MIROSLAV J. GASIC   +5 more
doaj   +7 more sources

Cytotoxic Terpene Quinones from Marine Sponges [PDF]

Marine Drugs, 2010
The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities.
Marina Gordaliza
doaj   +3 more sources

Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models

Drug and Chemical Toxicology, 2019
In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3′-methoxyavarone, 4′-(methylamino)avarone and 3′-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy ...
Branka Vuković-Gačić, Irena Novakovic, Dusan Sladić   +2 more
exaly   +8 more sources

Alkylamino and aralkylamino derivatives of avarone and its mimetic as selective agents against non-small cell lung cancer cells, their antibacterial and antifungal potential [PDF]

Journal of the Serbian Chemical Society, 2018
In this paper, the synthesis of fourteen alkylamino and arylamino derivatives of sesquiterpene quinone avarone and its model compound tert-butylquinone is described.
Jeremić Marko, Dinić Jelena, Pešić Milica, Stepanović Marija, Novaković Irena, Šegan Dejan, Sladić Dušan   +6 more
doaj   +2 more sources

Total Synthesis of Dactyloquinone A and Spiroetherone A via a Metal-Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol-Enedione Rearrangement. [PDF]

Angew Chem Int Ed Engl
Total syntheses of the meroterpenoid quinones dactyloquinone A and spiroetherone A were achieved from a common intermediate through the following original key steps: a metal‐hydride hydrogen atom transfer (MHAT) process with a quinone monoacetal in the case of dactyloquinone A, and a quinol–enedione rearrangement in the case of spiroetherone A ...
Schoenn G, Kouklovsky C, Guillot R, Magauer T, Vincent G.   +4 more
europepmc   +2 more sources