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Covalent modification of a glutamic acid inspired by HaloTag technology [PDF]
Nature CommunicationsFor targeted covalent protein modification at low-reactivity aspartates and glutamates, new methods are in high demand. We report a technique inspired by the HaloTag technology, which employs nucleophilic substitution at chloroalkane-functionalised ...
Ruirui Zhang +7 more
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Chemical proteomics reveals sinomenine’s anti-inflammatory mechanism through serum protein covalent modification [PDF]
Chinese MedicineBackground Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity.
Meixian Liu +7 more
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Uncoupling transcription from covalent histone modification. [PDF]
PLoS Genetics, 2014 It is widely accepted that transcriptional regulation of eukaryotic genes is intimately coupled to covalent modifications of the underlying chromatin template, and in certain cases the functional consequences of these modifications have been ...
Hesheng Zhang +3 more
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Effect of Ultrasonic Power on the Structural and Functional Properties of Gliadin Protein-Dietary Polyphenol Conjugates [PDF]
Shipin Kexue, 2023 In this study, free radical oxidation was chosen to induce covalent reaction of gliadin (GL) with epigallocatechin gallate. The effects of different ultrasound (US) powers on the enhancement of the covalent reaction were compared with the aim of ...
CAO Jiaxing, ZHU Hailan, WANG Junrong, ZHANG Jianhao, ZHANG Guozhi
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Modification of histidine repeat proteins by inorganic polyphosphate
Cell Reports, 2023 Summary: Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate that is present in nearly all organisms studied to date. A remarkable function of polyP involves its attachment to lysine residues via non-enzymatic post-translational ...
Nolan Neville +6 more
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Polyoxometalates, 2022 Covalently modified polyoxometalates (POMs), which benefit from the synergistic effect between POMs and covalently grafted moieties, have received increasing attention in various fields. Recent studies on covalently modified POMs mainly focus on function-
Huaiying Zhang +11 more
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Protein covalent modification of biologically active quinones [PDF]
Journal of the Serbian Chemical Society, 2004 The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of β-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione ...
Sladić Dušan M. +7 more
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Biomolecules, 2020 Fragment screening is a powerful tool to identify and characterize binding pockets in proteins. We herein present the results of a proof-of-concept screening campaign of a versatile 96-entry fragment library from our laboratory against the drug target ...
Steffen Glöckner +2 more
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A covalent BTK ternary complex compatible with targeted protein degradation
Nature Communications, 2023 Bridging covalent ligand discovery with chimeric degrader design has emerged as a mechanism to target proteins that lack enzymatic activity or are intractable.
James Schiemer +8 more
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Materials Research Express, 2021 Silicone rubber (SR) composites filled with silicone rubber particles (SRP) and functionalized h-BN platelets were successfully prepared, which have high thermal conductivities and flexibility.
Jiwan Ding +5 more
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