Results 31 to 40 of about 166,609 (297)

Regulation of G proteins by covalent modification [PDF]

Oncogene, 2001
Heterotrimeric G protein alpha,beta, and gamma subunits are subject to several kinds of co- and post-translational covalent modifications. Among those relevant to G protein-coupled receptor signaling in normal cell function are lipid modifications and phosphorylation. N-myristoylation is a co-translational modification occurring for members of the G(i)
C A, Chen, D R, Manning
openaire   +2 more sources

Technologies for Direct Detection of Covalent Protein–Drug Adducts

Pharmaceuticals, 2023
In the past two decades, drug candidates with a covalent binding mode have gained the interest of medicinal chemists, as several covalent anticancer drugs have successfully reached the clinic. As a covalent binding mode changes the relevant parameters to
Elma Mons, Robbert Q. Kim, Monique P. C. Mulder   +2 more
doaj   +1 more source

Amine-linked Covalent Organic Frameworks as a Powerful Platform for Post-Synthetic Modification: Structure Interconversion and Combined Linkage- and Pore-Wall-Modification

, 2020
Covalent organic frameworks have emerged as a powerful synthetic platform for installing and interconverting dedicated molecular functions on a crystalline polymeric backbone with atomic precision.
Igor, Moudrakovski, Viola, Duppel, Bettina, Lotsch, Gökcen, Savasci, Maxwell, Terban, Martin, Etter, Robert E., Dinnebier, Christian, Ochsenfeld, Lars, Grunenberg   +8 more
core   +1 more source

Dynamic covalent chemistry for site-selective protein modification

, 2022
Chemical modification of native biomacromolecules requires particularly mild reaction conditions: close to neutral pH, aqueous solvents, and physiological temperature.
Zegota, Maksymilian
core   +1 more source

Weighing the Proteasome for Covalent Modifications

Chemistry & Biology, 2015
Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive ...
Birner-Gruenberger, Ruth, Breinbauer, Rolf   +1 more
openaire   +2 more sources

Covalent Modifications of the Ebola Virus Glycoprotein [PDF]

Journal of Virology, 2002
ABSTRACT The role of covalent modifications of the Ebola virus glycoprotein (GP) and the significance of the sequence identity between filovirus and avian retrovirus GPs were investigated through biochemical and functional analyses of mutant GPs.
Scott A, Jeffers, David Avram, Sanders, Anthony, Sanchez   +2 more
openaire   +2 more sources

Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening

Bio-Protocol, 2020
Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for ...
Gregory Craven, David Mann, Alan Armstrong   +2 more
doaj   +1 more source

An internal thioester in a pathogen surface protein mediates covalent host binding [PDF]

, 2015
This work was supported by the MRC, UK grant MR/K001485 for MW, JME, MR, MJB, USL; the BBSRC, UK grant BB/J00453 and the John Innes Foundation for MJB; the Wellcome Trust Institutional Strategic Support Fund 097831/Z/11/B for AMD; Wellcome Trust/JIF ...
Kan, Su-Yin, Dziewulska, Aleksandra Malgorzata, Rohde, Manfred, Schwarz-Linek, Ulrich, Miriam Weckener, Shirran, Sally Lorna, Bergmann, Rene, Jackson, Rosemary J, Su-Yin Kan, Edwards, John Michael, Miller, Ona K, Banfield, Mark J, Aleksandra M Dziewulska, Schwarz-Linek, Uli, Florence, Gordon John, Saalbach, Gerhard, Rosemary J Jackson, Ulrich Schwarz-Linek, Catherine H Botting, Gerhard Saalbach, Dziewulska, Aleksandra M, Walden, Miriam, Jackson, Rosemary J., Mark J Banfield, Gordon J Florence, John M Edwards, Botting, Catherine H, Manfred Rohde, Banfield, Mark J., Sally L Shirran, Florence, Gordon J, Rene Bergmann, Weckener, Miriam, Miller, Ona Kealoha, Ona K Miller, Shirran, Sally L, Botting, Catherine Helen, Edwards, John M, Miriam Walden   +38 more
core   +1 more source

Chemical strategies for the covalent modification of filamentous phage [PDF]

Frontiers in Microbiology, 2014
Historically filamentous bacteriophage have been known to be the workhorse of phage display due to their ability to link genotype to phenotype. More recently, the filamentous phage scaffold has proven to be powerful outside the realm of phage display technology in fields such as molecular imaging, cancer research and materials, and vaccine development.
Matthew B Francis, Matthew B Francis, Jenna Marie Lee Bernard, Jenna Marie Lee Bernard   +3 more
openaire   +5 more sources

Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma

Frontiers in Pharmacology, 2021
Dimethyl fumarate (DMF) is an approved drug used in the treatment of multiple sclerosis (MS) and psoriasis therapy. Multiple studies have demonstrated other pharmacological activities of DMF such as an anti-cancer agent. In particular, studies have shown
Kaiyuan Chen, Shanshan Wu, Shanshan Wu, Sisi Ye, Sisi Ye, Huimin Huang, Yi Zhou, Hongfei Zhou, Shijia Wu, Yefan Mao, Fugen Shangguan, Linhua Lan, Bicheng Chen   +12 more
doaj   +1 more source