Template-assisted covalent modification underlies activity of covalent molecular glues. [PDF]
Nat Chem BiolMolecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and ...
Li YD +34 more
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Targeting an Intrinsically Disordered Protein by Covalent Modification
, 2020 Intrinsically disordered proteins (IDPs) play important roles in the regulation of cellular function and in disease, and thus they represent an important group of therapeutic targets.
Hung Huy Nguyen +15 more
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Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins. [PDF]
J Pept SciBioconjugation chemistry is an important tool for studying proteins, developing pharmaceutical agents, and for many other applications. Conventional methods for protein functionalization rely on chemoselective reactions but often have poor ...
Møller DN +3 more
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Organic covalent modification to improve thermoelectric properties of TaS2. [PDF]
Nat Commun, 2022 Organic semiconductors are attracting considerable attention as a new thermoelectric material because of their molecular diversity, non-toxicity and easy processing.
Wang S +5 more
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Amine-linked Covalent Organic Frameworks as a Powerful Platform for Post-Synthetic Modification: Structure Interconversion and Combined Linkage- and Pore-Wall-Modification [PDF]
, 2020 Covalent organic frameworks have emerged as a powerful synthetic platform for installing and interconverting dedicated molecular functions on a crystalline polymeric backbone with atomic precision.
Igor, Moudrakovski +8 more
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Covalent modification of proteins by cocaine [PDF]
Proceedings of the National Academy of Sciences, 2002 Cocaine covalently modifies proteins through a reaction in which the methyl ester of cocaine acylates the ɛ-amino group of lysine residues. This reaction is highly specific in vitro , because no other amino acid reacts with cocaine, and only cocaine's methyl ester reacts with the lysine side ...
Shi-Xian, Deng +3 more
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Calculating the Full Free Energy Profile for Covalent Modification of a Druggable Cysteine in Bruton’s Tyrosine Kinase [PDF]
, 2020 Targeted Covalent Inhibitors bind to their targets both covalent and non-covalent modes, providing exceptionally high affinity and selectivity. These inhibitors have been effectively employed as inhibitors of protein kinases, with Taunton and coworkers ...
Christopher, Rowley +1 more
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Covalent modifications of polysaccharides in mycobacteria [PDF]
Nature Chemical Biology, 2018 Mycobacteria produce carbohydrates of exceptional structures that are covalently modified by unique substituents, whose functional characterization could expand our understanding of how mycobacteria adapt to their environment.
Shiva k Angala +3 more
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Covalent lipid modifications of proteins [PDF]
Current Biology, 2013 SummaryAttachment of lipophilic groups is a widespread modification that occurs on nearly 1,000 proteins of diverse structure and function. At least five different types of lipids can be covalently attached to proteins: fatty acids, isoprenoids, sterols, phospholipids, and glycosylphosphatidyl inositol (GPI) anchors.
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Covalent modification of platelet proteins by palmitate [PDF]
Blood, 1989 Abstract Covalent attachment of fatty acid to proteins plays an important role in association of certain proteins with hydrophobic membrane structures. In platelets, the structure of many membrane glycoproteins (GPs) has been examined in detail, but the question of fatty acid acylation of platelet proteins has not been addressed. In this
L, Muszbek, M, Laposata
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