Results 11 to 20 of about 166,609 (297)

Template-assisted covalent modification underlies activity of covalent molecular glues. [PDF]

Nat Chem Biol
Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and ...
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL.   +34 more
europepmc   +4 more sources

Covalent post-assembly modification in metallosupramolecular chemistry [PDF]

Chemical Society Reviews, 2018
This review examines the growing variety of covalent reactions used to achieve the post-assembly modification of self-assembled metallosupramolecular complexes.
Derrick A. Roberts, Ben S. Pilgrim, Jonathan R. Nitschke   +2 more
core   +5 more sources

Covalent Modification Cycles through the Spatial Prism [PDF]

Biophysical Journal, 2013
Covalent modification cycles are basic units and building blocks of posttranslational modification and cellular signal transduction. We systematically explore different spatial aspects of signal transduction in covalent modification cycles by starting ...
Alam-Nazki, Aiman, Krishnan, J.
core   +3 more sources

A novel covalent modification of nitrogenase in a cyanobacterium

FEBS Letters, 2000
In extracts of the unicellular cyanobacterium Gloeothece, the Fe-protein of nitrogenase can be separated by SDS–PAGE into two antigenically identifiable components.
Dougherty, Lisa J., Smith, Christopher J., Pederson, Dennis M., Richards, Helen M., Victoria A. Gallon, Gallon, John R., Lisa J. Dougherty, Gallon, Victoria A., Jiujun Cheng, Helen M. Richards, Dennis M. Pederson, Sabrina Rüggeberg, John R. Gallon, Rüggeberg, Sabrina, Helmuth Hilz, Hilz, Helmuth, Christopher J. Smith, Cheng, Jiujun   +17 more
core   +3 more sources

Research Progress on Graphene/Polymer Composites with Non-covalent Surface Modification

Cailiao gongcheng, 2018
Graphene possesses excellent mechanical, electrical and thermal properties, which has been wildly used in modification of polymer composites. However, graphene has poor compatibility with polymers due to its surface inactive properties.
WANG Hao, ZHANG Hui, ZHANG Ji-hua, ZHAO Yun-feng   +3 more
doaj   +2 more sources

Targeting an Intrinsically Disordered Protein by Covalent Modification

, 2020
Intrinsically disordered proteins (IDPs) play important roles in the regulation of cellular function and in disease, and thus they represent an important group of therapeutic targets.
Hung Huy Nguyen, Keserű, György Miklós, Nguyen, Hung Huy, Ábrányi-Balogh, Péter, Attila Mészáros, Tompa, Peter, Kris Pauwels, Pauwels, Kris, László Petri, Peter Tompa, György Miklós Keserű, Vandenbussche, Guy, Meszaros, Attila, Guy Vandenbussche, Petri, László, Péter Ábrányi-Balogh   +15 more
core   +4 more sources

Organic covalent modification to improve thermoelectric properties of TaS₂. [PDF]

Nat Commun, 2022
Organic semiconductors are attracting considerable attention as a new thermoelectric material because of their molecular diversity, non-toxicity and easy processing.
Wang S, Yang X, Hou L, Cui X, Zheng X, Zheng J.   +5 more
europepmc   +2 more sources

Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins. [PDF]

J Pept Sci
Bioconjugation chemistry is an important tool for studying proteins, developing pharmaceutical agents, and for many other applications. Conventional methods for protein functionalization rely on chemoselective reactions but often have poor ...
Møller DN, Kofoed C, Thygesen MB, Jensen KJ.   +3 more
europepmc   +2 more sources

Covalent modification of proteins by cocaine [PDF]

Proceedings of the National Academy of Sciences, 2002
Cocaine covalently modifies proteins through a reaction in which the methyl ester of cocaine acylates the ɛ-amino group of lysine residues. This reaction is highly specific in vitro , because no other amino acid reacts with cocaine, and only cocaine's methyl ester reacts with the lysine side ...
Shi-Xian, Deng, Narine, Bharat, Marian C, Fischman, Donald W, Landry   +3 more
openaire   +2 more sources

Covalent modifications of polysaccharides in mycobacteria [PDF]

Nature Chemical Biology, 2018
Mycobacteria produce carbohydrates of exceptional structures that are covalently modified by unique substituents, whose functional characterization could expand our understanding of how mycobacteria adapt to their environment.
Shiva k Angala, Zuzana Palčeková, Juan M Belardinelli, Mary Jackson   +3 more
openaire   +2 more sources