Results 11 to 20 of about 2,379,457 (382)

Template-assisted covalent modification underlies activity of covalent molecular glues. [PDF]

Nat Chem Biol
Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and ...
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL.   +34 more
europepmc   +4 more sources

Organic covalent modification to improve thermoelectric properties of TaS₂. [PDF]

Nat Commun, 2022
Organic semiconductors are attracting considerable attention as a new thermoelectric material because of their molecular diversity, non-toxicity and easy processing.
Wang S, Yang X, Hou L, Cui X, Zheng X, Zheng J.   +5 more
europepmc   +2 more sources

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. [PDF]

J Am Chem Soc, 2022
KRAS mutations are one of the most common oncogenic drivers in human cancer. While small molecule inhibitors for the G12C mutant have been successfully developed, allele-specific inhibition for other KRAS hotspot mutants remains challenging.
Zhang Z, Morstein J, Ecker AK, Guiley KZ, Shokat KM.   +4 more
europepmc   +2 more sources

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. [PDF]

Angew Chem Int Ed Engl, 2021
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the ...
Fan S, Yue L, Wan W, Zhang Y, Zhang B, Otomo C, Li Q, Lin T, Hu J, Xu P, Zhu M, Tao H, Chen Z, Li L, Ding H, Yao Z, Lu J, Wen Y, Zhang N, Tan M, Chen K, Xie Y, Otomo T, Zhou B, Jiang H, Dang Y, Luo C.   +26 more
europepmc   +2 more sources

Covalent modification of a glutamic acid inspired by HaloTag technology [PDF]

Nature Communications
For targeted covalent protein modification at low-reactivity aspartates and glutamates, new methods are in high demand. We report a technique inspired by the HaloTag technology, which employs nucleophilic substitution at chloroalkane-functionalised ...
Ruirui Zhang, Jie Liu, Raphael Gasper, Anke Unger, Farnusch Kaschani, Markus Kaiser, Petra Janning, Herbert Waldmann   +7 more
doaj   +2 more sources

Protein covalent modification of biologically active quinones [PDF]

Journal of the Serbian Chemical Society, 2004
The avarone/avarol quinone/hydroquinone couple shows considerable antitumor activity. In this work, covalent modification of β-lactoglobulin by avarone and its derivatives as well as by the synthetic steroidal quinone 2,5(10)-estradiene- 1,4,17-trione ...
Sladić Dušan M., Novaković Irena, Vujčić Zoran M., Božić Tatjana T., Božić Nataša M., Milić Dragan, Šolaja Bogdan A., Gašić Miroslav J.   +7 more
doaj   +3 more sources

Amine-Linked Covalent Organic Frameworks as a Platform for Postsynthetic Structure Interconversion and Pore-Wall Modification

Journal of the American Chemical Society, 2021
Covalent organic frameworks have emerged as a powerful synthetic platform for installing and interconverting dedicated molecular functions on a crystalline polymeric backbone with atomic precision.
Lars Grunenberg, Gökçen Savaşçı, Maxwell W. Terban, Viola Düppel, Igor Moudrakovski, Martin Etter, Robert E. Dinnebier, Christian Ochsenfeld, Bettina V. Lotsch   +8 more
openalex   +2 more sources

Chemical proteomics reveals sinomenine’s anti-inflammatory mechanism through serum protein covalent modification

Chinese Medicine
Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity.
Meixian Liu, Zhiyuan Zheng, Yida Zhang, Xiqing Bian, Yue Zhuo, Hai-Ying Wu, Jian-Lin Wu, Na Li   +7 more
doaj   +2 more sources

Post-synthetic modification of covalent organic frameworks.

Chemical Society Reviews, 2019
Covalent organic frameworks (COFs) are organic porous materials with many potential applications, which very often depend on the presence of chemical functionality at the organic building blocks. Functionality that cannot be introduced into COFs directly
J. Segura, Sergio Royuela, Sergio Royuela, M. Ramos   +3 more
semanticscholar   +4 more sources

A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins. [PDF]

J Med Chem, 2020
Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice L, De Brabander JK, McFadden DG.   +11 more
europepmc   +3 more sources