Results 1 to 10 of about 89,225 (346)

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants

Frontiers in Plant Science, 2022
Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic ...
Jincheng Li, Manqi Zhang, Lijuan Zhou
doaj   +2 more sources

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function

Frontiers in Cell and Developmental Biology, 2021
Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki, Garrison Komaniecki, Hening Lin, Hening Lin, Hening Lin   +4 more
doaj   +2 more sources

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

eLife, 2021
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel
Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex   +8 more
doaj   +2 more sources

Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors [PDF]

Cell Communication and Signaling
Acylation modification plays a crucial role in tumor progression through altering protein homeostasis and localization. However, a comprehensive summary of these processes is lacking.
Jialin Jiang, Jiabin Chen, Shuhang Huang, Yue Tian, Lanyu Liu, Jiahui Yao, Yuzhu Zhang, Can Jiang, Xingting Zhang, Na Han, Guang Shu, Gang Yin, Li Xian Yip, Kuoran Xing, David Tai Leong, Maonan Wang   +15 more
doaj   +2 more sources

Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]

Open Biology, 2021
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain, Michael J. Shipston, Gwyn W. Gould   +2 more
doaj   +1 more source

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

Molecules and Cells, 2023
Summary p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets.
Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Ouyang Sheng, Fujing Wei, Zhuolin Wang, shao-Peng Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, Aimin Yang   +20 more
semanticscholar   +1 more source

Protein acylation: mechanisms, biological functions and therapeutic targets

Signal Transduction and Targeted Therapy, 2022
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
semanticscholar   +1 more source

Reversible 2′-OH acylation enhances RNA stability

Nature Chemistry, 2023
Stabilization of RNAs for storage, transport and biological application remains a profound challenge. Now, it has been shown that reversible 2′-OH acylation with easily accessible acylimidazoles unlocks efficient protection of RNA. RNA can be deprotected
L. Fang, Lu Xiao, Y. Jun, Yoshiyuki Onishi, E. Kool   +4 more
semanticscholar   +1 more source

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

bioRxiv, 2021
SARS-CoV-2 virions are surrounded by a lipid bilayer which contains membrane proteins such as Spike, responsible for target-cell binding and virus fusion, the envelope protein E and the accessory protein Orf3a.
F. Mesquita, L. Abrami, O. Sergeeva, P. Turelli, Enya Qing, B. Kunz, C. Raclot, J. Paz Montoya, L. Abriata, Thomas M. Gallagher, M. dal Peraro, D. Trono, G. D’Angelo, F. G. van der Goot   +13 more
semanticscholar   +1 more source

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Journal of experimental & clinical cancer research : CR, 2022
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation.
Yidian Fu, Jie Yu, Fang Li, S. Ge
semanticscholar   +1 more source