Results 1 to 10 of about 17,841 (206)

Palmitoylation in Renal Physiology and Pathology [PDF]

Biomolecules
Palmitoylation is a critical post-translational modification that involves the covalent binding of palmitic acid to cysteine residues within proteins.
Jingru Ma, Zhen Zhang, Jiaqi Guo, Hu Cai, Jian Yao, Dahai Yang, Huiyuan Zhu, Haijing Liu, Changhe Wang, Hongbo Xu   +9 more
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond

Cells, 2023
Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Chun-Wei Chen, Chen Chun-Wei   +2 more
exaly   +3 more sources

Protein palmitoylation in cancer: molecular functions and therapeutic potential

Molecular Oncology, 2023
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou
exaly   +2 more sources

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
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The Roles of Protein S-Palmitoylation in Cancers: From Dynamic Modulation to Therapeutic Potential [PDF]

Cancer Communications
Protein S-palmitoylation is a highly conserved posttranslational lipid modification that occurs on cysteine residues and critically influences protein maturation, subcellular localization, trafficking, and stability. Owing to its unique reversibility and
Haonan Zheng, Xiaoyu Sun, Yang Gao, Qinbiao Wang, Jiaqi Wang, Minjie Wei, Yu Tang, Miao He   +7 more
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From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions [PDF]

Cell Communication and Signaling
S-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse ...
Yue Zhu, Chunyu Ma, Liping Zhong, Tingting Wang, Weiwei Liu, Zishu Wang   +5 more
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The role of protein palmitoylation in disease pathogenesis and therapeutic innovation [PDF]

Annals of Medicine
Background Protein palmitoylation is a significant post-translational modification that influences protein stability, localization, and signaling through the addition of palmitoyl groups to cysteine, serine/threonine, or lysine residues.
Xinyue Lin, Jinshan Xing, Keran Jia, Shuang Liu, Yuzhou Liu, Yingjiang Gu, Kai Guo, Jingyan Yi   +7 more
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Palmitoylation-dependent regulation of innate and adaptive immunity: molecular insights and translational opportunities [PDF]

Cellular & Molecular Biology Letters
Immune cells orchestrate organismal defense through pathogen surveillance, tissue homeostasis, and immune tolerance, with innate and adaptive subsets coordinating context-specific responses.
Binhui Zhou, Bowen Zhang, Yingcheng Qi, Sainan Li, Tingting Liu, Tong Li, Ying Wang, Haifeng Wang, Jiaqi Lu, Fei Cao, Xiaohong Kang, Eryan Kong, Yinming Liang   +12 more
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Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
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Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source