Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential. [PDF]
Cell Death DiscovProtein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved from bacteria to mammals, plays critical role in metabolic processes. In humans, four identified lipoylated proteins serve as essential components
Li S +12 more
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Comparative Genomic Analysis Reveals 2-Oxoacid Dehydrogenase Complex Lipoylation Correlation with Aerobiosis in Archaea [PDF]
PLoS ONE, 2014 Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak +2 more
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Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis. [PDF]
Nat CommunCuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as ...
Hsiao JC +8 more
europepmc +2 more sources
Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein. [PDF]
Nat CommunLipoylation is a highly conserved post-translational modification (PTM) crucial for energy metabolism enzymes, with distinct pathways across organisms. Whereas bacteria like Escherichia coli inherit both salvage and de novo pathways, only the latter is ...
Yang R +7 more
europepmc +2 more sources
A response to iron involving carbon metabolism in the opportunistic fungal pathogen <i>Candida albicans</i>. [PDF]
mSphereIron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity.
Garg R +6 more
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Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress. [PDF]
Cell RepSummary: Phagocytic leukocytes employ reactive oxygen species to defend against pathogenic microorganisms. The bacterial pathogen Staphylococcus aureus adapts to oxidative stress by producing antioxidant enzymes and small molecules to protect proteins ...
Acosta IC +6 more
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FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation. [PDF]
Cell Death DiscovCholestatic liver injury, characterized by direct exposure of hepatocytes to retained bile components with elevated concentrations, represents a common manifestation of various hepatobiliary disorders with persistent threats to long-term patient survival
Guo Y +14 more
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BMEMatStimuli‐responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics.
Nannan Zheng +13 more
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Iron overload exaggerates renal ischemia-reperfusion injury by promoting tubular cuproptosis via interrupting function of LIAS. [PDF]
Redox BiolRenal ischemia-reperfusion injury (RIRI), a major contributor to acute kidney injury (AKI) and delayed graft function (DGF), is closely associated with dysregulation of metal ion homeostasis.
Chen S +6 more
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Genetic dissection of the mitochondrial lipoylation pathway in yeast
BMC Biology, 2021 Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of this ...
Laura P. Pietikäinen +4 more
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