Results 1 to 10 of about 4,253 (187)

Comparative Genomic Analysis Reveals 2-Oxoacid Dehydrogenase Complex Lipoylation Correlation with Aerobiosis in Archaea [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Steve Dorus, Mareike Posner   +2 more
exaly   +4 more sources

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential [PDF]

Cell Death Discovery
Protein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved from bacteria to mammals, plays critical role in metabolic processes. In humans, four identified lipoylated proteins serve as essential components
Sainan Li, Yingchao Liu, Wanye Hu, Aoli Deng, Xueying Ren, Lulu Chen, Yajuan Lu, Yunyi Wu, Hangqi Huang, Jinghao Cao, Jing Du, Jun Xia, Yanchun Li   +12 more
doaj   +3 more sources

Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications [PDF]

Frontiers in Cell and Developmental Biology
Cuproptosis is a regulated form of cell death triggered by copper overload and dependent on mitochondrial metabolism, particularly through FDX1-mediated protein lipoylation and TCA cycle disruption. Recent studies have revealed that epigenetic mechanisms,
Xin Zhang, Yixiao Yuan, Lin Tang, Juan Wang, Lincan Duan, Xiulin Jiang, Jia Zhang   +6 more
doaj   +2 more sources

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis [PDF]

Nature Communications
Cuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as ...
Jeffrey C. Hsiao, Douglas M. Warui, Jason J. Kwon, Margaret B. Dreishpoon, Nolan R. Bick, Tamra Blue-Lahom, David E. Root, Squire J. Booker, Peter Tsvetkov   +8 more
doaj   +2 more sources

Silencing SLC31A1 attenuates high glucose plus copper-induced cuproptosis-like signaling, oxidative stress, and barrier dysfunction in human retinal microvascular endothelial cells [PDF]

International Journal of Ophthalmology
AIM: To examine whether SLC31A1 knockdown protects human retinal microvascular endothelial cells (HRMECs) exposed to high glucose and copper. METHODS: HRMECs were exposed to normal glucose (5 mmol/L) or high glucose (30 mmol/L), with or without 50 μmol/L
Ying Li, Meng Chen, Han-Guang Dong
doaj   +2 more sources

Cuproptosis and prostate cancer: from molecular mechanisms and microenvironment remodeling to precision therapy [PDF]

Frontiers in Oncology
Prostate cancer (PCa) is a leading malignancy, and progression to castration-resistant prostate cancer (CRPC) remains a central therapeutic challenge.
Zhonghao Tang, Zhonghao Tang, Si Shen, Si Shen, Chen Guo, Chen Guo, Anjie Chen, Anjie Chen, Dongjie Yang, Jian Sun, Yuanyuan Mi   +10 more
doaj   +2 more sources

Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury [PDF]

Acta Pharmaceutica Sinica B
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is characterized by progressive loss of dopaminergic neurons in the substantia nigra.
Xiaomin Liang, Xunfang Yang, Shuhui Wang, Fangfang Zhuo, Xingzi Hou, Pengfei Tu, Yang Liu, Kewu Zeng, Qingying Zhang   +8 more
doaj   +2 more sources

Copper homeostasis and cuproptosis in tumor biology: mechanistic insights and clinical perspectives [PDF]

Frontiers in Immunology
Copper is considered a necessary trace element that plays crucial roles in energy production in mitochondria, redox regulation, and metabolism.
Zian Wang, Jiahao Xie, Yu Han, Xiaotao Zhang, Jinyu Song, Yu Xing, Binbin Hou, Cong Han, Yi Sui   +8 more
doaj   +2 more sources

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance [PDF]

Cancer Communications
Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking.
Weikai Wang, Xin Jiang, Xiaona Chen, Kaiyu Liang, Miaoqin Chen, Kaizhong Lu, Qi Wei, Yuchen Wu, Liyuan Zhu, Yuan Chen, Tianlun Hou, Jingfeng Luo, Chentao Li, Xian Wang, Hongchuan Jin, Lifeng Feng   +15 more
doaj   +2 more sources

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein [PDF]

Nature Communications
Lipoylation is a highly conserved post-translational modification (PTM) crucial for energy metabolism enzymes, with distinct pathways across organisms. Whereas bacteria like Escherichia coli inherit both salvage and de novo pathways, only the latter is ...
Runqing Yang, Yingying Wang, Minghua Kong, Zhijuan Hu, Zhe Zhang, Kun Shen, Jiali Meng, An-Ping Zeng   +7 more
doaj   +2 more sources