Results 31 to 40 of about 4,253 (187)
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
eLife, 2020 Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS).
Sara M Nowinski +18 more
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Frontiers in Chemistry, 2021 Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very ...
Sun Liu Rei Yan +4 more
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Frontiers in Plant Science, 2021 Lipoic acid (LA, 6,8-dithiooctanoic acid) is a sulfur containing coenzyme essential for the activity of several key enzymes involved in oxidative and single carbon metabolism in most bacteria and eukaryotes. LA is synthetized by the concerted activity of
Raquel Martins-Noguerol +8 more
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Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
Cell Reports, 2019 Summary: Inborn errors of metabolism (IEMs) link metabolic defects to human phenotypes. Modern genomics has accelerated IEM discovery, but assessing the impact of genomic variants is still challenging.
Min Ni +22 more
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A dual-function chemical probe for detecting erasers of lysine lipoylation
, 2022 Lysine lipoylation plays vital roles in cell metabolism and redox processes. For example, removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.
Xie, Y +6 more
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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes
mBio, 2017 Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on several multimeric enzyme complexes. These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism.
Elizabeth A. Rowland +5 more
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Crystallographic snapshots of sulfur insertion by lipoyl synthase [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Lipoic acid, an enzyme cofactor in central metabolism and a livestock feed supplement, is produced on an industrial scale by a costly multistep synthesis. Nature makes lipoic acid in one step by the chemically challenging addition of two sulfur atoms to an inert fatty acid chain.
Lanz, Nicholas D. +5 more
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Isolation of the Cadmium Derivative of Lipoyl Dehydrogenase
Journal of Biological Chemistry, 1971 Abstract Reduced lipoamide dehydrogenase reacts with cadmium ion to form a moderately stable compound characterized by 1 g atom of cadmium bound per mole of flavin adenine dinucleotide, a modified spectrum in the visible region, and altered reactivity with electron acceptor substrates.
A M, Stein, J H, Stein
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Lipoyl-E2-PDH Gets a Second Job [PDF]
Cell Host & Microbe, 2017 Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 subunit of PDH to suppress TLR-mediated activation of host macrophages by bacterial lipoproteins.
Seth W, Dickey, Michael, Otto
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A response to iron involving carbon metabolism in the opportunistic fungal pathogen Candida albicans
mSphereIron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity.
Ritu Garg +6 more
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