Toxicological Profile of the Pain-Relieving Antioxidant Compound Thioctic Acid in Its Racemic and Enantiomeric Forms [PDF]
Antioxidants, 2020 Thioctic acid is a multipotent antioxidant compound existing as dextrorotatory (+), eutomer and naturally occurring and levorotatory (−). It has been proven to help fight many pathologies and is sold as racemate.
Elena Lucarini +6 more
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Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain [PDF]
Frontiers in PharmacologyBackgroundNeuropathic pain is a chronic and often disabling condition that remains refractory to monotherapy because of limited efficacy and dose-limiting adverse effects.
Edith Zárate +3 more
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Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders [PDF]
Materials Today BioHemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal ...
Yuesheng Tu +12 more
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Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling [PDF]
Future Science OAAim: Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.Materials & methods: The brain-derived neurotrophic factor (BDNF), metabotropic glutamate receptor ...
Mai O. Kadry, Rehab M. Abdel-Megeed
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Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy [PDF]
Therapeutics and Clinical Risk Management, 2011 Courtney E McIlduff, Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USABackground: The most common of the neuropathies associated with diabetes mellitus, diabetic sensorimotor polyneuropathy (DSPN) is a ...
McIlduff CE, Rutkove SB
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Comparative Dissolution Kinetics of Several Multisource Thioctic Acid Products
Регуляторные исследования и экспертиза лекарственных средств, 2022 The relationship between dissolution and bioavailability is an example of the interdependency between the quality of a medicinal product and its safety and efficacy.
G. F. Vasilenko +6 more
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Thioctic Acid Derivatives as Building Blocks to Incorporate DNA Oligonucleotides onto Gold Nanoparticles [PDF]
Molecules, 2014 Oligonucleotide gold nanoparticle conjugates are being used as diagnostic tools and gene silencing experiments. Thiol-chemistry is mostly used to functionalize gold nanoparticles with oligonucleotides and to incorporate DNA or RNA molecules onto gold ...
Sónia Pérez-Rentero +4 more
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Modern Approaches to the Technology of Tablet Dosage Forms of Thioctic Acid (Review)
Разработка и регистрация лекарственных средств, 2021 Introduction. Thioctic (α-lipoic) acid is an endogenous antioxidant and is used for liver diseases, poisoning with salts of heavy metals, hyperlipidemia, atherosclerotic heart disease, neuropathy, insulin-resistant forms of diabetes mellitus, etc ...
S. N. Egorova +4 more
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Beneficial effects of vincamine with thioctic acid and lutein on retinal and optic nerve functions in an opaque media [PDF]
International Journal of Ophthalmology, 2019 AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or not. METHODS: Totally 2000 patients (2000 eyes) of
Mona Abdelkader +4 more
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Protective effects of the R-(+)-thioctic acid treatment: possible anti-inflammatory activity on heart of hypertensive rats [PDF]
BMC Complementary Medicine and TherapiesBackground In cardiovascular disease, high blood pressure is associated with oxidative stress, promoting endothelial dysfunction, vascular remodeling, and inflammation. Clinical trials are discordant that the most effective treatment in the management of
Proshanta Roy +6 more
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