Results 11 to 20 of about 4,253 (187)

Genetic dissection of the mitochondrial lipoylation pathway in yeast [PDF]

BMC Biology, 2021
Background Lipoylation of 2-ketoacid dehydrogenases is essential for mitochondrial function in eukaryotes. While the basic principles of the lipoylation processes have been worked out, we still lack a thorough understanding of the details of this ...
Laura P. Pietikäinen, M. Tanvir Rahman, J. Kalervo Hiltunen, Carol L. Dieckmann, Alexander J. Kastaniotis   +4 more
doaj   +7 more sources

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. [PDF]

PLoS Pathogens, 2007
Lipoic acid (LA) is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Svenja Günther, Lynsey Wallace, Eva-Maria Patzewitz, Paul J McMillan, Janet Storm, Carsten Wrenger, Ryan Bissett, Terry K Smith, Sylke Müller   +8 more
doaj   +2 more sources

Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. [PDF]

PLoS ONE, 2012
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health.
Stuart Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Pieter de Jong, Dejiang Feng, Loren Fong, Yiping Tu, Yan Hu, Stephen G Young, Thomas Pham, Carling Cheung, Shana M Katzman, Martin D Brand, Casey L Quinlan, Marcel Fens, Frans Kuypers, Stephanie Misquitta, Stephen M Griffey, Son Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal-Bach, Grace Wang, Sandra Larkin, Jennifer Thweatt, Saloni Pasta   +27 more
doaj   +3 more sources

LipoFNT: Lipoylation Sites Identification with Flexible Neural Tree

Complexity, 2019
Lysine lipoylation is a special type of posttranslational modification in both prokaryotes’ and eukaryotes’ proteomics researches. Such a modification takes part in several significant biological processions and plays a key role in the cellular level. In
Wenzheng Bao, Bin Yang, Rong Bao, Yuehui Chen   +3 more
doaj   +2 more sources

ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation [PDF]

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression.
Lu Yang, Xuhui Li, Yutong Jiang, Mingzhu Zhang, Tiantian Wu, Peixian Pi, Zhuozhuo Han, Zhiyu Zhang, Fangyuan Kong, Xiuhong Lu, Hao Yang, Chaohui Zuo, Gang Huang, Jian Zhao, Beibei Liang   +14 more
doaj   +2 more sources

ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex [PDF]

Nature Communications, 2020
2-oxoglutarate links mitochondrial metabolism to oxygen sensing, gene transcription and epigenetic modifications. Here, the authors describe a mutagenesis screen to find genes that control 2-oxoglutarate levels, and identify ABHD11 as a mitochondrial ...
Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S. H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan   +8 more
doaj   +18 more sources

Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids

Nature Communications, 2023
Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S.
Wen Fang, Liu Jiang, Yibing Zhu, Sen Yang, Hong Qiu, Jiou Cheng, Qingxi Liang, Zong-cai Tu, Cunqi Ye   +8 more
doaj   +2 more sources

Impairment of Lipoylation Mediated by Bromooctanoate Targets Eukaryotic Amidotransferases

Molecular Microbiology
ABSTRACTLipoylation is a post‐translational modification in which lipoic acid is attached to specific apoproteins of enzyme complexes, like E2 subunits of dehydrogenases or GcvH of the glycine cleavage system. A defining feature of organisms with a lipoyl‐relay system is the presence of amidotransferase activity, which enables the transfer of lipoyl ...
Albertina Scattolini, Joaquín Costa, Tulio L. Pianessi, Antonio D. Uttaro, María C. Mansilla   +4 more
openaire   +3 more sources

Irritable Bowel Disease: Think Malonic and Methylmalonic Aciduria (CMAMMA)! [PDF]

JIMD Rep
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA; OMIM 614265) is a rare disorder of mitochondrial fatty acid synthesis caused by pathogenic variants in the ACSF3 gene, which encodes malonyl‐CoA synthetase. The clinical presentation is highly heterogeneous and may include seizures, memory impairment, psychiatric manifestations, and ...
Alatibi K, Hug MJ, Tucci S.
europepmc   +2 more sources

DLST Succinylation-Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma. [PDF]

Adv Sci (Weinh)
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Li X, Zhou P, Peng X, Liu Q, Zeng W, Wang R, Shen L, Peng J, Zhou Q, Yang L.   +9 more
europepmc   +2 more sources