Results 1 to 10 of about 8,409 (203)

Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators

iMeta, 2023
Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a way that has never been characterized before, which is dependent on mitochondrial stress and is referred to as “cuproptosis.” The role of ...
Qing Liu
exaly   +2 more sources

Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science
Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy of cuproptosis remains limited by the poor delivery efficiency of copper ion carriers. Herein, copper complex nanoparticles
Qionghua Jin
exaly   +2 more sources

Molecular subtypes, tumor microenvironment infiltration characterization and prognosis model based on cuproptosis in bladder cancer [PDF]

PeerJ, 2023
Cuproptosis is a kind of cell death dependent on copper. We aimed to explore the functions of the cuproptosis in the tumor microenvironment (TME) and construct a cuproptosis-related prognosis signature in bladder cancer (BCa).
Heping Zhang, Ji Liu, Zongtai Zheng
doaj   +2 more sources

Revealing prognostic and tumor microenvironment characteristics of cuproptosis in bladder cancer by genomic analysis

Frontiers in Genetics, 2022
Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Shun Zhang, Shenggen Yu, Huangqi Duan, Weimin Xia, Chen Wang, Haibo Shen   +5 more
doaj   +1 more source

Identification of cuproptosis-related subtypes, characterization of immune microenvironment infiltration, and development of a prognosis model for osteoarthritis

Frontiers in Immunology, 2023
BackgroundOsteoarthritis (OA) is a prevalent chronic joint disease with an obscure underlying molecular signature. Cuproptosis plays a crucial role in various biological processes.
Jiao Nong, Guanyu Lu, Yue Huang, Jinfu Liu, Lihua Chen, Haida Pan, Bo Xiong   +6 more
doaj   +1 more source

Identification of cuproptosis-related patterns and construction of a scoring system for predicting prognosis, tumor microenvironment-infiltration characteristics, and immunotherapy efficacy in breast cancer

Frontiers in Oncology, 2022
BackgroundCuproptosis, a recently discovered refreshing form of cell death, is distinct from other known mechanisms. As copper participates in cell death, the induction of cancer cell death with copper ionophores may emerge as a new avenue for cancer ...
Wei Li, Xingda Zhang, Yanbo Chen, Da Pang, Da Pang   +4 more
doaj   +1 more source

Analysis of cuproptosis in hepatocellular carcinoma using multi-omics reveals a comprehensive HCC landscape and the immune patterns of cuproptosis

Frontiers in Oncology, 2022
Cuproptosis represents a novel copper-dependent regulated cell death, distinct from other known cell death processes. In this report, a comprehensive analysis of cuproptosis in hepatocellular carcinoma (HCC) was conducted using multi-omics including ...
Xinqiang Li, Xinqiang Li, Peng Jiang, Peng Jiang, Ruixia Li, Bin Wu, Bin Wu, Kai Zhao, Kai Zhao, Shipeng Li, Jinzhen Cai, Jinzhen Cai   +11 more
doaj   +1 more source

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li   +7 more
doaj   +1 more source

Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma

Frontiers in Genetics, 2022
Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang, Chen Zhang, Chengyue Ji, Wenli Jin, Xin He, Shunzhi Yu, Renhua Guo   +6 more
doaj   +1 more source

Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims

Frontiers in Cell and Developmental Biology, 2022
Cuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified.
Binxiang Chu, Haihong Zheng, Xiaohe Zheng, Xingbing Feng, Zhenghua Hong   +4 more
doaj   +1 more source