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Pan‐cancer analyses reveal molecular and clinical characteristics of cuproptosis regulators
iMeta, 2023 Imbalance in copper homeostasis can be lethal. A recent study found that excess copper induces cell death in a way that has never been characterized before, which is dependent on mitochondrial stress and is referred to as “cuproptosis.” The role of ...
Qing Liu
exaly +2 more sources
Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer
Frontiers in Immunology, 2022 Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this is quite different from the common cell death patterns such as apoptosis, pyroptosis, necroptosis, and ferroptosis.
Qiang Song +4 more
exaly +3 more sources
Cuproptosis as a novel predictor of immunotherapy response and shapes the immune landscape in pan-cancer analysis [PDF]
Discover OncologyThe heterogeneity of cancer renders its response to immunotherapy elusive, warranting the identification of robust biomarkers for evaluation. As a form of recently defined regulated cell death (RCD), cuproptosis is driven by copper-dependent proteotoxic ...
Yitong Pan, Xiaodi Hu, Jun Cheng
doaj +2 more sources
View, 2023 Cuproptosis, the current form of regulated cell death characterized by copper overload, oligomerization of lipoacylated proteins, and loss of Fe–S cluster proteins, has been proposed to function closely with human diseases, including cancer.
Qinrui Fu
exaly +2 more sources
Frontiers in Immunology, 2022 Cuproptosis, or copper-induced cell death, has been reported as a novel noncanonical form of cell death in recent times. However, the potential roles of cuproptosis in the alteration of tumor clinicopathological features and the formation of a tumor ...
Weng Junyong +2 more
exaly +3 more sources
Multi-omics integration identifies ARID1B linking cuproptosis-immune crosstalk with atherosclerotic plaque progression [PDF]
Frontiers in GeneticsBackgroundAtherosclerosis is a long-term inflammatory disorder of the arterial wall, characterized by lipid deposition and infiltration of immune cells.
Xinyan Hu +4 more
doaj +2 more sources
Advanced ScienceCuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy of cuproptosis remains limited by the poor delivery efficiency of copper ion carriers. Herein, copper complex nanoparticles
Qionghua Jin
exaly +2 more sources
MT2A-Mediated Regulation of Cuproptosis in Human Dental Pulp Cells Modulates Macrophage M1 Polarization in Pulpitis [PDF]
International Dental JournalBackground: The progression of pulpitis is strongly affected by the fate of dental pulp cells, with their modes of cell death determining whether inflammation resolves or leads to irreversible necrosis.
Yiming Zhong +7 more
doaj +2 more sources
Molecular subtypes, tumor microenvironment infiltration characterization and prognosis model based on cuproptosis in bladder cancer [PDF]
PeerJ, 2023 Cuproptosis is a kind of cell death dependent on copper. We aimed to explore the functions of the cuproptosis in the tumor microenvironment (TME) and construct a cuproptosis-related prognosis signature in bladder cancer (BCa).
Heping Zhang, Ji Liu, Zongtai Zheng
doaj +2 more sources
Frontiers in Genetics, 2022 Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Shun Zhang +5 more
doaj +1 more source