Results 31 to 40 of about 5,930 (180)

Systematic analysis of the aberrances and functional implications of cuproptosis in cancer

iScience, 2023
Summary: Cuproptosis is a novel form of cell death driven by a copper-dependent proteotoxic stress response whose comprehensive landscape in tumors remains unclear. Here, we comprehensively characterized cuproptosis-related genes (CRGs) across 33 cancers
Jiangbing Li, Boyan Li, Rongrong Zhao, Gang Li   +3 more
doaj   +1 more source

Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis

Frontiers in Molecular Biosciences, 2023
Cuproptosis is a novel form of cell death linked to mitochondrial metabolism and is mediated by protein lipoylation. The mechanism of cuproptosis in many diseases, such as psoriasis, remains unclear.
Qingyuan Lin, Qingyuan Lin, Jinchao Zhu, Jinchao Zhu, Jun Chen, Shouqiang Jia, Shengdong Nie   +6 more
doaj   +1 more source

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder

Frontiers in Immunology, 2023
BackgroundUrothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available.
Huan Feng, Huan Feng, Huan Feng, Huan Feng, Zhiyao Deng, Zhiyao Deng, Zhiyao Deng, Yibao Huang, Zhuo Liu, Zhuo Liu, Yajun Ruan, Yajun Ruan, Tao Wang, Tao Wang, Tao Wang, Jihong Liu, Jihong Liu   +16 more
doaj   +1 more source

Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer

Nature Communications, 2023
Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown.
Lianhui Sun, Yuan Zhang, Boyu Yang, Sijun Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guangjian Fan, Chen Huang   +12 more
doaj   +1 more source

Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma

Frontiers in Immunology, 2023
Cuproptosis, a newly identified form of programmed cell death, plays vital roles in tumorigenesis. However, the interconnectivity of cuproptosis and ferroptosis is poorly understood.
Yefeng Shen, Yefeng Shen, Deyu Li, Qiong Liang, Mengsi Yang, Youguang Pan, Hui Li   +6 more
doaj   +1 more source

Identification of cuproptosis-related subtypes, cuproptosis-related gene prognostic index in hepatocellular carcinoma

Frontiers in Immunology, 2022
Cuproptosis is a novel form of cell death, correlated with the tricarboxylic acid (TCA) cycle. However, the metabolic features and the benefit of immune checkpoint inhibitor (ICI) therapy based on cuproptosis have not yet been elucidated in Hepatocellular carcinoma (HCC).
Lei Ding, Wei Li, Jili Tu, Zhixing Cao, Jizheng Li, Haiming Cao, Junjie Liang, Yiming Liang, Qiangfeng Yu, Gencong Li   +9 more
openaire   +3 more sources

Impact of Cuproptosis-related markers on clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: A multi-omic analysis

Computational and Structural Biotechnology Journal, 2023
Background: Cuproptosis, a novel identified cell death form induced by copper, is characterized by aggregation of lipoylated mitochondrial enzymes and the destabilization of Fe–S cluster proteins.
Yanfei Shao, Xiaodong Fan, Xiao Yang, Shuchun Li, Ling Huang, Xueliang Zhou, Sen Zhang, Minhua Zheng, Jing Sun   +8 more
doaj   +1 more source

A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis

Frontiers in Immunology, 2023
BackgroundCuproptosis, the most recently identified and regulated cell death, depends on copper ions in vivo. Copper regulates the pathogenesis of Idiopathic pulmonary fibrosis (IPF), but the mechanism of action underlying cuproptosis in IPF remains ...
Chuanqing Jing, Rong Fu, Xue Liu, Guodong Zang, Xue Zhu, Can Wang, Wei Zhang   +6 more
doaj   +1 more source

Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma

Biology Direct, 2023
Background Cuproptosis is a new type of copper-induced cell death that is characterized by the aggregation of lipoylated tricarboxylic acid (TCA) cycle proteins. However, its role in hepatocellular carcinoma (HCC) remains unclear.
Yuqiao Chen, Lu Tang, Wentao Huang, Fakolade Hannah Abisola, Youyu Zhang, Gewen Zhang, Lei Yao   +6 more
doaj   +1 more source

A novel cuproptosis-related prognostic signature and potential value in HCC immunotherapy

Frontiers in Molecular Biosciences, 2022
Background: Copper metabolism plays an important role in the tumor microenvironment, and cuproptosis is the last discovered programmed cell death process.
Xiang-Xu Wang, Li-Hong Wu, Hongchen Ji, Qing-Qing Liu, Shi-Zhou Deng, Qiong-Yi Dou, Liping Ai, Wei Pan, Hong-Mei Zhang   +8 more
doaj   +1 more source