Results 51 to 60 of about 8,409 (203)

Role of cuproptosis-related gene in lung adenocarcinoma

Frontiers in Oncology, 2022
BackgroundsLung adenocarcinoma (LUAD) is the most common subtype of lung cancer, which is the leading cause of cancer death. Dysregulation of cell proliferation and death plays a crucial role in the development of LUAD.
Yuan Liu, Wei Lin, Ying Yang, JingJing Shao, Hongyu Zhao, Gaoren Wang, Aiguo Shen   +6 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Comprehensive analysis of cuproptosis-related genes and tumor microenvironment infiltration characterization in breast cancer

Frontiers in Immunology, 2022
BackgroundCuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. The positive response to immunotherapy, one of the most important treatments for invasive breast cancer ...
Shaoran Song, Shaoran Song, Miao Zhang, Miao Zhang, Peiling Xie, Shuhong Wang, Yaochun Wang, Yaochun Wang   +7 more
doaj   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

DataSheet3_Revealing prognostic and tumor microenvironment characteristics of cuproptosis in bladder cancer by genomic analysis.XLSX

, 2022
Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Haibo Shen (4412893), Shun Zhang (334141), Chen Wang (88408), Weimin Xia (11750027), Huangqi Duan (7440791), Shenggen Yu (13895607)   +5 more
core   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Image3_Revealing prognostic and tumor microenvironment characteristics of cuproptosis in bladder cancer by genomic analysis.TIF

, 2022
Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Haibo Shen (4412893), Shun Zhang (334141), Chen Wang (88408), Weimin Xia (11750027), Huangqi Duan (7440791), Shenggen Yu (13895607)   +5 more
core   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Image2_Revealing prognostic and tumor microenvironment characteristics of cuproptosis in bladder cancer by genomic analysis.TIF

, 2022
Objectives: Bladder cancer (BLCA) is the most common malignant tumor in the urinary system, while the prognosis of muscle-invasive bladder cancer (MIBC) is poor. Cuproptosis might be a promising therapeutic approach to trigger tumor cell death.
Haibo Shen (4412893), Shun Zhang (334141), Chen Wang (88408), Weimin Xia (11750027), Huangqi Duan (7440791), Shenggen Yu (13895607)   +5 more
core   +1 more source

Cuproptosis‐related molecular patterns and gene (ATP7A) in hepatocellular carcinoma and their relationships with tumor immune microenvironment and clinical features

Cancer Reports, 2023
Background Cuproptosis has been studied in various aspects as a new form of cell death. Aims We hope to explore the molecular patterns and genes related to cuproptosis in evaluating and predicting the prognosis of hepatocellular carcinoma (HCC), as well ...
Shanbao Li, Junyong Weng, Chao Xiao, Jing Lu, Wanyue Cao, Fangbin Song, Zeping He, Peng Zhang, Zhonglin Zhu, Junming Xu   +9 more
doaj   +1 more source