Results 41 to 50 of about 8,409 (203)

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder

Frontiers in Immunology, 2023
BackgroundUrothelial carcinoma of the bladder (UCB) is the most prevalent malignant tumor of the urinary system worldwide, which has a significant recurrence rate despite multiple treatment options available.
Huan Feng, Huan Feng, Huan Feng, Huan Feng, Zhiyao Deng, Zhiyao Deng, Zhiyao Deng, Yibao Huang, Zhuo Liu, Zhuo Liu, Yajun Ruan, Yajun Ruan, Tao Wang, Tao Wang, Tao Wang, Jihong Liu, Jihong Liu   +16 more
doaj   +1 more source

Cuproptosis in ccRCC: key player in therapeutic and prognostic targets [PDF]

, 2023
BackgroundClassical biomarkers have been used to classify clear cell renal cell carcinoma (ccRCC) patients in a variety of ways, and emerging evidences have indicated that cuproptosis is closely related to mitochondrial metabolism, thereby accelerating ...
Chao Qin, Yang Lv, Lu Yin, Qiang Li, Shaohua He, Zhongwen Lu, Hongqi Chen   +6 more
core   +1 more source

A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis

Frontiers in Immunology, 2023
BackgroundCuproptosis, the most recently identified and regulated cell death, depends on copper ions in vivo. Copper regulates the pathogenesis of Idiopathic pulmonary fibrosis (IPF), but the mechanism of action underlying cuproptosis in IPF remains ...
Chuanqing Jing, Rong Fu, Xue Liu, Guodong Zang, Xue Zhu, Can Wang, Wei Zhang   +6 more
doaj   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Engineering ZCIF@GSK Nanoplatform to Overcome Tumor Metabolism: LDHA Inhibition-Mediated Cuproptosis for Highly Efficient Oncotherapy. [PDF]

Adv Healthc Mater
Cuproptosis, heavily dependent on copper and mitochondrial tricarboxylic acid (TCA) cycle, can be exploited as a potential oncotherapy. However, the primary metabolic pathway of tumor cells is dependent on glycolysis owing to the overexpression of ...
Yin SY, Lv G, Ma L, Bu D, Zheng H, Guo J, Zhang Z, Zhang X, Dong R.   +8 more
europepmc   +2 more sources

Induction of Methuosis in Breast Cancer Stem Cells by a Cobalt(III) Complex Evokes Immunotherapeutic Response

Angewandte Chemie, EarlyView.
Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang, Sijie Wen, Xiao Feng, Hao Ren, Kuldip Singh, Haihua Xiao, Lingpu Zhang, Kogularamanan Suntharalingam   +7 more
wiley   +2 more sources

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

A novel cuproptosis-related prognostic signature and potential value in HCC immunotherapy

Frontiers in Molecular Biosciences, 2022
Background: Copper metabolism plays an important role in the tumor microenvironment, and cuproptosis is the last discovered programmed cell death process.
Xiang-Xu Wang, Li-Hong Wu, Hongchen Ji, Qing-Qing Liu, Shi-Zhou Deng, Qiong-Yi Dou, Liping Ai, Wei Pan, Hong-Mei Zhang   +8 more
doaj   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source