Results 61 to 70 of about 5,930 (180)

Sulfasalazine Enhances Copper Toxicity in Danio rerio Larvae: Divergent Protective Roles of Deferoxamine and Ferrostatin‐1

Environmental Toxicology, EarlyView.
ABSTRACT Copper is an environmental contaminant capable of disrupting redox homeostasis and impairing antioxidant defenses in aquatic organisms, thereby increasing susceptibility to oxidative stress. The cystine/glutamate antiporter (system xc−) plays a central role in maintaining intracellular glutathione (GSH) levels, a major antioxidant defense ...
Maria Vitória Takemura Mariano, Pedro Henrique Vicenzi, Vitor Oliveira de Rosso, Mauro Eugênio Medina Nunes, Layla da Silva Braga, Analía Del Valle Garnero, Ricardo José Gunski, Marcelo Farina, Thaís Posser, Jeferson Luis Franco   +9 more
wiley   +1 more source

Copper, Cuproptosis, and Neurodegenerative Diseases

International Journal of Molecular Sciences
Copper is a vital micronutrient for animals and plants acting as a crucial cofactor in the synthesis of numerous metabolic enzymes and contributing to mitochondrial respiration, metabolism, oxido-reductive reactions, signal transmission, and oxidative and nitrosative damage.
Giuseppe Genchi, Alessia Catalano, Alessia Carocci, Maria Stefania Sinicropi, Graziantonio Lauria   +4 more
openaire   +2 more sources

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

The role of cuproptosis in gastric cancer

Frontiers in Immunology
As a biologically essential transition metal, copper is widely involved in various enzymatic reactions and crucial biological processes in the body. It plays an increasingly important role in maintaining normal cellular metabolism and supporting the growth and development of the human body.
Yixian Li, Wenhao Sun, Shaolin Yuan, Xinxin Liu, Ziqi Zhang, Renjun Gu, Pengfei Li, Xin Gu   +7 more
openaire   +3 more sources

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, EarlyView.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

Cell Proliferation, EarlyView.
Schematic diagram for the experimental design for adaptome immune repertoire analysing Dampness ZHENG across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis. ABSTRACT Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide.
Lipeng Tang, Maojie Wang, Yuhong Yan, Shumin Qin, Youbang Liang, Danni Yao, Liyan Mei, Hao Deng, Shuyan Ye, Xiumin Chen, Kaixin Gao, Xirun Zheng, Taohua Liu, Xinmin Qiu, Song Li, Xinjie Yu, Wenjing Pan, Shaogang Huang, Zhe Wang, Runyue Huang, Guangjuan Zheng, Chuanjian Lu   +21 more
wiley   +1 more source

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

Signal Transduction and Targeted Therapy
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form ...
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng   +9 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source