Results 81 to 90 of about 8,409 (203)

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

Signal Transduction and Targeted Therapy
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form ...
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng   +9 more
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, EarlyView.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis [PDF]

Bowen Wei,1,2,* Siwei Wang,1,2,* Suiran Li,1,2,* Qingxiang Gu,3 Qingyun Yue,4 Zhuo Tang,1,2 Jiamin Zhang,1,2 Wei Liu1,2 1Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine ...
Tang Z, Wei B, Li S, Zhang J, Wang S, Yue Q, Gu Q, Liu W   +7 more
core  

Table1_Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma.DOCX

, 2022
Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang (171069), Chen Zhang (66790), Shunzhi Yu (460154), Renhua Guo (392942), Wenli Jin (13946172), Xin He (48101), Chengyue Ji (8304621)   +6 more
core   +1 more source

ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression.
Lu Yang, Xuhui Li, Yutong Jiang, Mingzhu Zhang, Tiantian Wu, Peixian Pi, Zhuozhuo Han, Zhiyu Zhang, Fangyuan Kong, Xiuhong Lu, Hao Yang, Chaohui Zuo, Gang Huang, Jian Zhao, Beibei Liang   +14 more
doaj   +1 more source

Image1_Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma.TIF

, 2022
Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang (171069), Chen Zhang (66790), Shunzhi Yu (460154), Renhua Guo (392942), Wenli Jin (13946172), Xin He (48101), Chengyue Ji (8304621)   +6 more
core   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Exploring Cuproptosis-Related Genes and Diagnostic Models in Renal Ischemia-Reperfusion Injury Using Bioinformatics, Machine Learning, and Experimental Validation [PDF]

Changhong Xu,1,* Yun Deng,1,* Xinyi Gong,2,* Huabin Wang,1 Jiangwei Man,1 Hailong Wang,1 Kun Cheng,1 Huiming Gui,1 Shengjun Fu,1 Shenghu Wei,3 Xiaoling Zheng,4 Tuanjie Che,4 Liyun Ding,3 Li Yang1 1Department of Urology, Institute of Urology ...
Fu S, Zheng X, Yang L, Xu C, Wang H, Gong X, Man J, Ding L, Che T, Wei S, Cheng K, Gui H, Deng Y   +12 more
core  

Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death

Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications.
Xinyi Tang, Liang Dong, Guangsen Li, Xujun Yu, Nihong Li, Yanxin Guan, Fang Yang, Junjun Li, Renbin Yuan, Hong Wang, Bin Li   +10 more
core   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source