Results 81 to 90 of about 5,930 (180)

Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosis

Frontiers in Immunology
BackgroundDistant metastasis of colorectal cancer (CRC) significantly impacts patient prognosis. Cuproptosis is a new form of copper ion-dependent cell death. However, whether cuproptosis-related genes (CRGs) play a role in the metastatic potential of CRC remains unclear.
HuiE Zhuang, Yizhen Chen, Yizhen Chen, Sifu Huang   +3 more
openaire   +3 more sources

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis

Communications Biology
Cuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu, Linjing Long, Min Wang, Lianli Shen, Jianjun Hu, Huijun Tang, Shufen Feng, Xiongxiu Liu, Ying Shi, Shaohui Tang, Yanfang Chen   +10 more
doaj   +1 more source

Epigallocatechin Gallate Promotes Cuproptosis via the MTF1/ATP7B Axis in Hepatocellular Carcinoma

Cells
Background: Cuproptosis is a form of copper-dependent non-apoptotic cell death. Cancer cells that prefer to use aerobic glycolysis for energy generation are commonly insensitive to cuproptosis, which hinders its application for cancer treatment ...
Yuhan Fu, Lirui Hou, Kai Han, Chong Zhao, Hongbo Hu, Shutao Yin   +5 more
doaj   +1 more source

Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death

Cell Death Discovery
Abstract Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications.
Junjun Li, Nihong Li, Hong Wang, Bin Li, Xinyi Tang, Yanxin Guan, Fang Yang, Guangsen Li, Liang Dong, Renbin Yuan, Xujun Yu   +10 more
openaire   +3 more sources

Immunomodulation of cuproptosis and ferroptosis in liver cancer

Cancer Cell International
AbstractAccording to statistics, the incidence of liver cancer is increasing yearly, and effective treatment of liver cancer is imminent. For early liver cancer, resection surgery is currently the most effective treatment. However, resection does not treat the disease in advanced patients, so finding a method with a better prognosis is necessary.
Jia-qian Mo, Shen-yan Zhang, Qiang Li, Mo-xian Chen, Yue-qing Zheng, Xin Xie, Rongxin Zhang, Shan-shan Wang   +7 more
openaire   +3 more sources

Copper Homeostasis and Cuproptosis in Neurological Disorders

Drug Design, Development and Therapy
Neurological disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) pose a serious global public health threat, with complex etiologies involving genetic, environmental, and metabolic factors. Current data indicate that the prevalence of these disorders is rapidly increasing with the aging population, resulting in a growing economic ...
Wu Liu, Yan Xue, Chenyin Cao, Liting Yang, Lijun Zhang   +4 more
openaire   +3 more sources

Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer

Cellular & Molecular Biology Letters
Background Cuproptosis is a unique copper-dependent form of cell death that is highly correlated with the metabolic state of cells. Triptolide exerts pharmacological activity by altering the regulation of metal ions.
Yanxia Xiao, Jiameng Yin, Pu Liu, Xin Zhang, Yajun Lin, Jun Guo   +5 more
doaj   +1 more source

Novel insights into cuproptosis inducers and inhibitors

Frontiers in Molecular Biosciences
Cuproptosis is a new pattern of Cu-dependent cell death distinct from classic cell death pathways and characterized by aberrant lipoylated protein aggregation in TCA cycle, Fe-S cluster protein loss, HSP70 elevation, proteotoxic and oxidative stress aggravation.
Ligang Zhang, Ligang Zhang, Ruiting Deng, Lian Liu, Hongli Du, Dongsheng Tang   +5 more
openaire   +3 more sources

The molecular mechanism of cuproptosis and research progress in pancreatic diseases

Annals of Medicine
Purpose Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis.
Qizhi Wang, Huijun Chen, Zhen Lv, Peng Zhang, Yingxiao Li, Chuanliang Zhao, Shengqiang Li   +6 more
doaj   +1 more source

Copper homeostasis and cuproptosis in health and disease

MedComm
AbstractCopper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation of various biological processes. Regulation of copper levels within a narrow range is imperative for maintaining metabolic homeostasis.
Yunuo Yang, Jiaxuan Wu, Lisheng Wang, Guang Ji, Yanqi Dang   +4 more
openaire   +3 more sources