Results 91 to 100 of about 5,930 (180)

Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives

Journal of Hematology & Oncology
Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation of dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial ...
Chenliang Zhang, Tingting Huang, Liping Li   +2 more
doaj   +1 more source

Copper homeostasis and cuproptosis in gynecological cancers

Frontiers in Cell and Developmental Biology
Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, a novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death.
Xiaodi Huang, Xiaodi Huang, Xiaodi Huang, Mengyi Lian, Changzhong Li, Changzhong Li, Changzhong Li   +6 more
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Pharmacologically Targeting Ferroptosis and Cuproptosis in Neuroblastoma

Molecular Neurobiology
Neuroblastoma is a deadly pediatric cancer that originates from the neural crest and frequently develops in the abdomen or adrenal gland. Although multiple approaches, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, are recommended for treating neuroblastoma, the tumor will eventually develop resistance, leading to treatment ...
Liu, Ying, Fleishman, Joshua S., Wang, Hongquan, Huo, Liang   +3 more
openaire   +2 more sources

Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis

Biomolecules
Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardiomyopathy, according to recent ...
Mohammad El-Nablaway, Hany M. A. Sonpol, Yaser Hosny Ali Elewa, Mohamed A. M. Ali, Mohamed Adel, Eman Serry Zayed, Maha Alhelf, Manar A. Didamoony, Amal Fahmy Dawood, Eman M. Embaby, Khaled S. El-Bayoumi, Wesam S. El-Saeed   +11 more
doaj   +1 more source

DACT1 inhibits cuproptosis and promotes cell malignancy via activation of PI3K/AKT signaling in laryngeal squamous cell carcinoma

European Journal of Medical Research
Background Laryngeal cancer has one of the highest mortality rates of all head and neck cancers. DACT1 is a cuproptosis-related gene in laryngeal cancer and serves as a risk factor for patient prognosis.
Yan Guo, Jiarui Zhang, Jingchun Ge, Liang Li, Ming Liu, Linli Tian   +5 more
doaj   +1 more source

Identification and immunological role of cuproptosis in osteoporosis

Heliyon
osteoporosis is a skeletal disorder disease features low bone mass and poor bone architecture, which predisposes to increased risk of fracture. Copper death is a newly recognized form of cell death caused by excess copper ions, which presumably involve in various disease.
Tongying Chen, Zhijie Gao, Yuedong Wang, Jiachun Huang, Shuhua Liu, Yanping Lin, Sai Fu, Lei Wan, Ying Li, Hongxing Huang, Zhihai Zhang   +10 more
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Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
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Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy

Nature Communications
Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by tumor cells resist under specific mechanisms.
Meng Guan, Kai Cheng, Xiao-Ting Xie, Yong Li, Meng-Wen Ma, Bin Zhang, Si Chen, Wei Chen, Bo Liu, Jin-Xuan Fan, Yuan-Di Zhao   +10 more
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Comprehensive analysis and validation of the prognostic significance of cuproptosis-related genes in rectal adenocarcinoma

Frontiers in Cell and Developmental Biology
BackgroundRectal adenocarcinoma has a high incidence and suboptimal therapeutic outcomes. Notably, reliable prognostic biomarkers are currently lacking.
Tianhao Li, Tianhao Li, Xinyu Gao, Xinyu Gao, Shuocun Zhang, Haoren Jing, Haoren Jing, Haoren Jing, Zhicheng Pu, Zhicheng Pu, Zhicheng Pu, Xipeng Zhang, Xipeng Zhang, Xipeng Zhang, Mingqing Zhang, Mingqing Zhang, Mingqing Zhang   +16 more
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Cuproptosis: Biomarkers, Mechanisms and Treatments in Diseases

Molecules
The homeostasis balance of copper, as an essential trace element for life activities, is crucial for maintaining the normal function of cells. Cuproptosis, discovered in recent years, is a novel type of programmed cell death triggered by the accumulation of excessive copper ions in mitochondria.
Wang, Shuhui, Zhang, Jian, Zhou, Yanyan
openaire   +2 more sources