Results 101 to 110 of about 8,409 (203)

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Copper-mediated SEC14L3 promotes cuproptosis to inhibit hepatocellular carcinoma growth via ERK/YY1/FDX1 axis

Communications Biology
Cuproptosis, a copper-triggered cell death pathway, holds therapeutic potential for cancers, but its regulatory mechanisms in hepatocellular carcinoma (HCC) remain undefined.
Chutian Wu, Linjing Long, Min Wang, Lianli Shen, Jianjun Hu, Huijun Tang, Shufen Feng, Xiongxiu Liu, Ying Shi, Shaohui Tang, Yanfang Chen   +10 more
doaj   +1 more source

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

Cell Proliferation, EarlyView.
Schematic diagram for the experimental design for adaptome immune repertoire analysing Dampness ZHENG across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis. ABSTRACT Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide.
Lipeng Tang, Maojie Wang, Yuhong Yan, Shumin Qin, Youbang Liang, Danni Yao, Liyan Mei, Hao Deng, Shuyan Ye, Xiumin Chen, Kaixin Gao, Xirun Zheng, Taohua Liu, Xinmin Qiu, Song Li, Xinjie Yu, Wenjing Pan, Shaogang Huang, Zhe Wang, Runyue Huang, Guangjuan Zheng, Chuanjian Lu   +21 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer

Cellular & Molecular Biology Letters
Background Cuproptosis is a unique copper-dependent form of cell death that is highly correlated with the metabolic state of cells. Triptolide exerts pharmacological activity by altering the regulation of metal ions.
Yanxia Xiao, Jiameng Yin, Pu Liu, Xin Zhang, Yajun Lin, Jun Guo   +5 more
doaj   +1 more source

Cuproptosis and anti-tumor immunity: bidirectional regulation, controversies, and translational prospects

Frontiers in Immunology
Cuproptosis is a copper-dependent form of regulated cell death driven by copper binding to lipoylated tricarboxylic acid (TCA) cycle proteins. This interaction triggers aberrant protein aggregation, Fe-S cluster protein degradation, and mitochondrial ...
Xiangxiang Ren, Tianhao Xie, Xiaoshi Jin, Meng Zhang   +3 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

The molecular mechanism of cuproptosis and research progress in pancreatic diseases

Annals of Medicine
Purpose Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis.
Qizhi Wang, Huijun Chen, Zhen Lv, Peng Zhang, Yingxiao Li, Chuanliang Zhao, Shengqiang Li   +6 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, Volume 13, Issue 49, 3 September 2026.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer

Cuproptosis, a recently identified copper-dependent form of regulated cell death, is driven by mitochondrial dysfunction caused by copper overload.
Gan, Yu, Zhou, Xiang, Hao, Qian
core   +1 more source