Results 21 to 30 of about 8,409 (203)

A novel cuproptosis-related molecular pattern and its tumor microenvironment characterization in colorectal cancer

Frontiers in Immunology, 2022
Cuproptosis, or copper-induced cell death, has been reported as a novel noncanonical form of cell death in recent times. However, the potential roles of cuproptosis in the alteration of tumor clinicopathological features and the formation of a tumor ...
Zhonglin Zhu, Zhonglin Zhu, Qiuyan Zhao, Qiuyan Zhao, Wang Song, Wang Song, Junyong Weng, Junyong Weng, Shanbao Li, Tianan Guo, Tianan Guo, Congcong Zhu, Congcong Zhu, Ye Xu, Ye Xu   +14 more
doaj   +1 more source

cuproptosis

, 2022
   In patients with GC, the cuproptosis- and cisplatin resistance-related signature could help predict prognosis, biological traits, immunotherapy effects, and cisplatin sensitivity.
Dazhi Zhou (14161440)
core   +1 more source

EP300-Mediated MTF1-K218 Lactylation Buffers AR-Driven Copper Overload to Suppress Cuproptosis in Castration-Resistant Prostate Cancer. [PDF]

Adv Sci (Weinh)
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Li K, Wei Y, Li Y, Dong Y, Lv J, Yuan M, Shen A, Liu F, Zhang Y, Li Y, Yu R, Liu Y, Zhao T, Wang J, Zhou K, Fan Z, Wang M, Xu J, Du M, Gu M, Yao B, Zhu Q.   +21 more
europepmc   +2 more sources

Cell death mediated by nanotechnology via the cuproptosis pathway: A novel horizon for cancer therapy

View, 2023
Cuproptosis, the current form of regulated cell death characterized by copper overload, oligomerization of lipoacylated proteins, and loss of Fe–S cluster proteins, has been proposed to function closely with human diseases, including cancer.
Chuang Wei, Qinrui Fu
doaj   +1 more source

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Frontiers in Genetics, 2022
Background: Cuproptosis is a novel type of cell death induced by copper. Cuproptosis-associated genes play a crucial part in oncogenesis and the growth and metastasis of tumors.
Jinsong Liu, Yueyao Lu, Yuyang Dai, Ying Shen, Cheng Zeng, Xiuling Liu, Huayi Yu, Jianzhong Deng, Wenbin Lu, Wenbin Lu, Wenbin Lu   +10 more
doaj   +1 more source

Cuproptosis-related lncRNAs potentially predict prognosis and therapy sensitivity of breast cancer

Frontiers in Pharmacology, 2023
Background: Cuproptosis-related lncRNAs regulate the biological functions of various cancers. However, the role of cuproptosis-related lncRNAs in breast cancer remains unclear.
Xiwen Wu, Ying Zhang, Gehao Liang, Huizhen Ye   +3 more
doaj   +1 more source

Expression Profiles of Cuproptosis-Related Genes Determine Distinct Subtypes of Pancreatic Ductal Adenocarcinoma

Current Oncology, 2023
Background: Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent subtype of pancreatic cancer and one of the most malignant tumors worldwide. Due to the heterogeneity of its genomics and proteomics, the prognosis of PDAC remains disappointing ...
Yusheng Chen, Xuan Zou, Mingjian Ma, Yu Liu, Ruijie Wang, Zhengjie Dai, Yesiboli Tashiheng, Yu Yan, Xianjun Yu, Xu Wang, Chen Liu, Xuan Lin, He Cheng   +12 more
doaj   +1 more source

Comprehensive analysis of cuproptosis‐related gene expression and positive correlations with CD4+ T cell infiltration in head and neck squamous cell carcinoma

MedComm – Oncology, 2023
Cuproptosis is a novel form of copper‐induced programmed cell death. Here, we investigate the role of cuproptosis‐related genes in head and neck squamous cell carcinoma (HNSCC), and the correlations between cuproptosis‐related genes and tumor ...
Zhangwei Hu, Wenbin Lei, Weiping Wen
doaj   +1 more source

UBE2D4 Upregulation Promotes Cuproptosis Sensitivity in Colorectal Cancer. [PDF]

Mol Genet Genomic Med
UBE2D4 is genetically upregulated in colorectal cancer and its expression status modulates copper‐induced cuproptosis sensitivity. Copper overload induces UBE2D4 and DLAT expression; UBE2D4 knockdown attenuates DLAT induction and rescues cell viability, suggesting UBE2D4 as a genetic determinant of cuproptosis sensitivity and a potential stratification
Wang B, Li C, Guo X, Liang Z.
europepmc   +2 more sources

Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma

Frontiers in Immunology, 2023
Cuproptosis, a newly identified form of programmed cell death, plays vital roles in tumorigenesis. However, the interconnectivity of cuproptosis and ferroptosis is poorly understood.
Yefeng Shen, Yefeng Shen, Deyu Li, Qiong Liang, Mengsi Yang, Youguang Pan, Hui Li   +6 more
doaj   +1 more source