Results 21 to 30 of about 5,930 (180)

Comprehensive Analysis of Cuproptosis Genes and Identification of Cuproptosis Subtypes in Breast Cancer

Combinatorial Chemistry & High Throughput Screening, 2023
Background: Copper-induced death (cuproptosis) is copper-dependent regulated cell death, which is different from known death mechanisms and is dependent on mitochondrial respiration. However, its effect on breast cancer (BRCA) is unclear. Objective: The objective of this study is to explore the important clinical significance of cuproptosis genes ...
Li, Jialin, Li, Lei, Dong, Yi, Zhong, Bin, Yin, Wei   +4 more
openaire   +2 more sources

Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims

Frontiers in Cell and Developmental Biology, 2022
Cuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified.
Binxiang Chu, Haihong Zheng, Xiaohe Zheng, Xingbing Feng, Zhenghua Hong   +4 more
doaj   +1 more source

Cuproptosis: mechanisms and links with cancers

Molecular Cancer, 2023
AbstractCuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of ...
Jiaming Xie, Yannan Yang, Yibo Gao, Jie He   +3 more
openaire   +3 more sources

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Frontiers in Immunology, 2022
BackgroundThough immune checkpoint inhibitors (ICIs) exhibit durable efficacy in bladder carcinomas (BLCAs), there are still a large portion of patients insensitive to ICIs treatment.MethodsWe systematically evaluated the cuproptosis patterns in BLCA ...
Huihuang Li, Huihuang Li, Xiongbing Zu, Xiongbing Zu, Jiao Hu, Jiao Hu, Zicheng Xiao, Zicheng Xiao, Zhiyong Cai, Zhiyong Cai, Ning Gao, Ning Gao, Jinbo Chen, Jinbo Chen   +13 more
doaj   +1 more source

Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma

European Journal of Medical Research, 2023
Objective The latest research proposed a novel copper-dependent programmed cell death named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal cell carcinoma (ccRCC) from a multi-omic perspective.
Maoshu Zhu, Yongsheng Li, Yun Wang, Pingli Lin, Jun Mi, Weimin Zhong   +5 more
doaj   +1 more source

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Frontiers in Genetics, 2022
Background: Cuproptosis is a novel type of cell death induced by copper. Cuproptosis-associated genes play a crucial part in oncogenesis and the growth and metastasis of tumors.
Jinsong Liu, Yueyao Lu, Yuyang Dai, Ying Shen, Cheng Zeng, Xiuling Liu, Huayi Yu, Jianzhong Deng, Wenbin Lu, Wenbin Lu, Wenbin Lu   +10 more
doaj   +1 more source

Cuproptosis-related lncRNAs potentially predict prognosis and therapy sensitivity of breast cancer

Frontiers in Pharmacology, 2023
Background: Cuproptosis-related lncRNAs regulate the biological functions of various cancers. However, the role of cuproptosis-related lncRNAs in breast cancer remains unclear.
Xiwen Wu, Ying Zhang, Gehao Liang, Huizhen Ye   +3 more
doaj   +1 more source

Role of cuproptosis in understanding diseases

Human Cell, 2023
Cell death is involved in a wide range of physiological and pathological processes. Recently, the term "cuproptosis" was coined to describe a novel type of cell death. This type of cell death, characterized by copper accumulation and proteotoxic stress, is a copper-dependent manner of death.
Shihan Cao, Qian Wang, Zhenzhen Sun, Yue Zhang, Qianqi Liu, Qun Huang, Guixia Ding, Zhanjun Jia   +7 more
openaire   +2 more sources

Expression Profiles of Cuproptosis-Related Genes Determine Distinct Subtypes of Pancreatic Ductal Adenocarcinoma

Current Oncology, 2023
Background: Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent subtype of pancreatic cancer and one of the most malignant tumors worldwide. Due to the heterogeneity of its genomics and proteomics, the prognosis of PDAC remains disappointing ...
Yusheng Chen, Xuan Zou, Mingjian Ma, Yu Liu, Ruijie Wang, Zhengjie Dai, Yesiboli Tashiheng, Yu Yan, Xianjun Yu, Xu Wang, Chen Liu, Xuan Lin, He Cheng   +12 more
doaj   +1 more source

Comprehensive analysis of cuproptosis‐related gene expression and positive correlations with CD4+ T cell infiltration in head and neck squamous cell carcinoma

MedComm – Oncology, 2023
Cuproptosis is a novel form of copper‐induced programmed cell death. Here, we investigate the role of cuproptosis‐related genes in head and neck squamous cell carcinoma (HNSCC), and the correlations between cuproptosis‐related genes and tumor ...
Zhangwei Hu, Wenbin Lei, Weiping Wen
doaj   +1 more source