Results 11 to 20 of about 8,409 (203)

Recent progress of methods for cuproptosis detection [PDF]

Frontiers in Molecular Biosciences
Varying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading ...
Ligang Zhang, Ligang Zhang, Ruiting Deng, Raoqing Guo, Yawen Jiang, Yichen Guan, Caiyue Chen, Wudi Zhao, Guobin Huang, Lian Liu, Hongli Du, Dongsheng Tang   +11 more
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Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures
Cuproptosis, a recently identified copper‐dependent metabolic cell death pathway, eliminates tumor cell via toxic aggregation of lipoylated enzymes in the tricarboxylic acid cycle.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
doaj   +2 more sources

Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis [PDF]

Frontiers in Molecular Biosciences, 2023
Cuproptosis is a novel form of cell death linked to mitochondrial metabolism and is mediated by protein lipoylation. The mechanism of cuproptosis in many diseases, such as psoriasis, remains unclear.
Qingyuan Lin, Qingyuan Lin, Jinchao Zhu, Jinchao Zhu, Jun Chen, Shouqiang Jia, Shengdong Nie   +6 more
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Cuproptosis in stroke: focusing on pathogenesis and treatment [PDF]

Frontiers in Molecular Neuroscience
Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition.
Liwei Xing, Zhifeng Wang, Zhihui Hao, Pan Pan, Aiming Yang, Jian Wang   +5 more
doaj   +2 more sources

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat
Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications. Recent findings that copper can induce programmed cell death (cuproptosis) not only in eukaryotes but also in bacteria ...
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
doaj   +2 more sources

SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway. [PDF]

Kaohsiung J Med Sci
ABSTRACT Cisplatin (CDDP) resistance constitutes the principal clinical challenge in the treatment of advanced non‐small cell lung cancers (NSCLC). Disturbances in copper metabolism are closely linked with tumor drug resistance. SOX2, a pivotal stemness transcription factor (TF), holds an important role in chemotherapy resistance.
Chen K, He FM, Huang YH, Fang T, Zheng YP, Cai JF.   +5 more
europepmc   +2 more sources

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis-Mediated Positive Feedback Loop. [PDF]

Adv Sci (Weinh)
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Feng W, Yang R, Weng C, Li C, Shi W, Chen Y, Yang Y, Liu Y, Ge P, Zhang H.   +9 more
europepmc   +2 more sources

Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer

Frontiers in Immunology, 2022
Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this is quite different from the common cell death patterns such as apoptosis, pyroptosis, necroptosis, and ferroptosis.
Qiang Song, Qiang Song, Rui Zhou, Fangpeng Shu, Wen Fu   +4 more
doaj   +1 more source

Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma

European Journal of Medical Research, 2023
Objective The latest research proposed a novel copper-dependent programmed cell death named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal cell carcinoma (ccRCC) from a multi-omic perspective.
Maoshu Zhu, Yongsheng Li, Yun Wang, Pingli Lin, Jun Mi, Weimin Zhong   +5 more
doaj   +1 more source

Cuproptosis depicts tumor microenvironment phenotypes and predicts precision immunotherapy and prognosis in bladder carcinoma

Frontiers in Immunology, 2022
BackgroundThough immune checkpoint inhibitors (ICIs) exhibit durable efficacy in bladder carcinomas (BLCAs), there are still a large portion of patients insensitive to ICIs treatment.MethodsWe systematically evaluated the cuproptosis patterns in BLCA ...
Huihuang Li, Huihuang Li, Xiongbing Zu, Xiongbing Zu, Jiao Hu, Jiao Hu, Zicheng Xiao, Zicheng Xiao, Zhiyong Cai, Zhiyong Cai, Ning Gao, Ning Gao, Jinbo Chen, Jinbo Chen   +13 more
doaj   +1 more source