Results 11 to 20 of about 5,930 (180)

Cuproptosis in osteoarthritis: Exploring chondrocyte cuproptosis and therapeutic avenues

Journal of Orthopaedic Translation
Background: Cuproptosis, a newly identified form of cell death, presents an as-yet-unclear potential correlation with Osteoarthritis (OA) pathogenesis. This study aimed to explore the relationship between chondrocyte cuproptosis and OA, and to evaluate ...
Haotian Hua, Feng Cheng, Zhuo Meng, Anqi Zhang, Mengying Li, Minjie Zhang, Pengqiang Lou, Yiwen Zhu, Peijian Tong, Yang Zhang   +9 more
doaj   +4 more sources

Recent progress of methods for cuproptosis detection

Frontiers in Molecular Biosciences
Varying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading ...
Ligang Zhang, Ligang Zhang, Ruiting Deng, Raoqing Guo, Yawen Jiang, Yichen Guan, Caiyue Chen, Wudi Zhao, Guobin Huang, Lian Liu, Hongli Du, Dongsheng Tang   +11 more
doaj   +3 more sources

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures
Cuproptosis, a recently identified copper‐dependent metabolic cell death pathway, eliminates tumor cell via toxic aggregation of lipoylated enzymes in the tricarboxylic acid cycle.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
doaj   +2 more sources

Cuproptosis in stroke: focusing on pathogenesis and treatment

Frontiers in Molecular Neuroscience
Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition.
Liwei Xing, Zhifeng Wang, Zhihui Hao, Pan Pan, Aiming Yang, Jian Wang   +5 more
doaj   +3 more sources

Identification of cuproptosis-related patterns and construction of a scoring system for predicting prognosis, tumor microenvironment-infiltration characteristics, and immunotherapy efficacy in breast cancer

Frontiers in Oncology, 2022
BackgroundCuproptosis, a recently discovered refreshing form of cell death, is distinct from other known mechanisms. As copper participates in cell death, the induction of cancer cell death with copper ionophores may emerge as a new avenue for cancer ...
Wei Li, Xingda Zhang, Yanbo Chen, Da Pang, Da Pang   +4 more
doaj   +1 more source

Identification of cuproptosis-related subtypes, characterization of immune microenvironment infiltration, and development of a prognosis model for osteoarthritis

Frontiers in Immunology, 2023
BackgroundOsteoarthritis (OA) is a prevalent chronic joint disease with an obscure underlying molecular signature. Cuproptosis plays a crucial role in various biological processes.
Jiao Nong, Guanyu Lu, Yue Huang, Jinfu Liu, Lihua Chen, Haida Pan, Bo Xiong   +6 more
doaj   +1 more source

Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundDue to the different infiltration abundance of immune cells in tumor, the efficacy of immunotherapy varies widely among individuals. Recently, growing evidence suggested that cuproptosis has impact on cancer immunity profoundly.
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li   +7 more
doaj   +1 more source

Molecular subtypes based on cuproptosis-related genes and immune profiles in lung adenocarcinoma

Frontiers in Genetics, 2022
Background: Recent studies have identified several molecular subtypes of lung adenocarcinoma (LUAD) that have different prognoses to help predict the efficacy of immunotherapy. However, the prognostic prediction is less than satisfactory.
Yufei Wang, Chen Zhang, Chengyue Ji, Wenli Jin, Xin He, Shunzhi Yu, Renhua Guo   +6 more
doaj   +1 more source

Analysis of cuproptosis in hepatocellular carcinoma using multi-omics reveals a comprehensive HCC landscape and the immune patterns of cuproptosis

Frontiers in Oncology, 2022
Cuproptosis represents a novel copper-dependent regulated cell death, distinct from other known cell death processes. In this report, a comprehensive analysis of cuproptosis in hepatocellular carcinoma (HCC) was conducted using multi-omics including ...
Xinqiang Li, Xinqiang Li, Peng Jiang, Peng Jiang, Ruixia Li, Bin Wu, Bin Wu, Kai Zhao, Kai Zhao, Shipeng Li, Jinzhen Cai, Jinzhen Cai   +11 more
doaj   +1 more source

Cuproptosis and cuproptosis–related genes in rheumatoid arthritis: Implication, prospects, and perspectives

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is an autoimmune disease that severely affects patients’ physical and mental health, leading to chronic synovitis and destruction of bone joints. Although various available clinical treatment options exist, patients respond with varying efficacies due to multiple factors, and there is an urgent need to discover new treatment ...
Jianan Zhao, Jianan Zhao, Jianan Zhao, Shicheng Guo, Shicheng Guo, Steven J. Schrodi, Steven J. Schrodi, Dongyi He, Dongyi He, Dongyi He, Dongyi He   +10 more
openaire   +3 more sources