Results 21 to 30 of about 4,253 (187)

Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation

, 2019
Lysine lipoylation, a highly conserved lysine post-translational modification, plays a critical role in regulating cell metabolism. The catalytic activity of a number of vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lysine ...
Hongyan Sun (327879), Rui Wang (52434), Yusheng Xie (2186521), Wei Xu (28953), Yingxue Li (705766), Jingyu Li (324429), Lanfang Chen (3355439), Shao Q. Yao (1525546), Liang Zhang (41392), Quan Hao (67204), Jigang Wang (730916)   +10 more
core   +6 more sources

Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart. [PDF]

Sci Adv
The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear.
Rumyantseva A, Tippetts TS, Wilhalm A, Carter W, Moedas M, Rosenberger FA, Moore D, Végvári Á, Hinze Y, Muellner-Wong L, Alsina D, Wibom R, Winston R, Mathews TP, Lund LH, Andersson DC, Pironti G, Wedell A, DeBerardinis RJ, Freyer C, Wredenberg A.   +20 more
europepmc   +2 more sources

Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System

Frontiers in Genetics, 2021
Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine.
Kit-Yi Leung, Sandra C. P. De Castro, Gabriel L. Galea, Andrew J. Copp, Nicholas D. E. Greene   +4 more
doaj   +1 more source

Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma

Frontiers in Medicine, 2022
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors.
Hanwen Lu, Hanwen Lu, Liwei Zhou, Liwei Zhou, Bingchang Zhang, Bingchang Zhang, Yuanyuan Xie, Yuanyuan Xie, Huiyin Yang, Huiyin Yang, Zhanxiang Wang, Zhanxiang Wang, Zhanxiang Wang   +12 more
doaj   +1 more source

An Essential Role of Mitochondrial α-Ketoglutarate Dehydrogenase E2 in the Basal Immune Response Against Bacterial Pathogens in Tomato

Frontiers in Plant Science, 2020
Plants intensely modulate respiration when pathogens attack, but the function of mitochondrial respiration-related genes in plant–bacteria interaction is largely unclear.
Qiaomei Ma, Yaru Liu, Hanmo Fang, Ping Wang, Golam Jalal Ahammed, Wenshan Zai, Kai Shi   +6 more
doaj   +1 more source

FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis

Heliyon, 2023
Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen, Jianan Zhang, Weifeng Teng, Yong Luo, Xiaochun Ji   +4 more
doaj   +1 more source

An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration

Nature Communications, 2023
Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty acid products has remained unclear.
M. Tanvir Rahman, M. Kristian Koski, Joanna Panecka-Hofman, Werner Schmitz, Alexander J. Kastaniotis, Rebecca C. Wade, Rik K. Wierenga, J. Kalervo Hiltunen, Kaija J. Autio   +8 more
doaj   +1 more source

Differential Effects of Mercurial on the Lipoyl Reductase and Diaphorase Activities of Lipoyl Dehydrogenase

Journal of Biological Chemistry, 1966
Abstract The sensitivity of lipoyl dehydrogenase to phenylmercuric acetate, a reagent for —SH groups, has been investigated. Titration of available sulfhydryl groups in the enzyme brings about inactivation in the reduced diphosphopyridine nucleotide-lipoyl reductase activity, while activity with the artificial hydrogen acceptor 2,6-dichloroindophenol ...
L, Casola, V, Massey
openaire   +2 more sources

Ilipo-pseaac: Identification of lipoylation sites using statistical moments and general pseaac

, 2022
Lysine Lipoylation is a protective and conserved Post Translational Modification (PTM) in proteomics research like prokaryotes and eukaryotes. It is connected with many biological processes and closely linked with many metabolic diseases.
Gillani, Durdana Qaiser, Khan, Yaser Daanial, Alam, Talha Mahboob, Biswal, Bharat, Baig, Talha Imtiaz, Aljuaid, Hanan   +5 more
core   +1 more source

Proteomic analysis reveals a novel function of the kinase Sat4p in Saccharomyces cerevisiae mitochondria. [PDF]

PLoS ONE, 2014
The Saccharomyces cerevisiae kinase Sat4p has been originally identified as a protein involved in salt tolerance and stabilization of plasma membrane transporters, implicating a cytoplasmic localization. Our study revealed an additional mitochondrial (mt)
Uta Gey, Cornelia Czupalla, Bernard Hoflack, Udo Krause, Gerhard Rödel   +4 more
doaj   +1 more source