Results 1 to 10 of about 2,610 (155)
FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis
Heliyon, 2023 Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen +4 more
exaly +5 more sources
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis [PDF]
Nature CommunicationsCuproptosis is a recently described form of regulated cell death triggered by ionophore-induced copper (Cu) overload in mitochondria. It is critically dependent on ferredoxin 1 (FDX1), a mitochondrial iron-sulfur cluster containing protein that acts as ...
Jeffrey C. Hsiao +8 more
doaj +4 more sources
LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer
Redox BiologyBackground: Cuproptosis, a copper-dependent form of regulated cell death, has emerged as a redox-sensitive vulnerability in cancer. However, the molecular basis by which this process is initiated and sustained in tumors remains poorly defined.
, Zhuoran Sun, Jingjing Jiang
exaly +5 more sources
Ferrodoxin 1 (FDX1) drives paclitaxel resistance in ovarian cancer via copper metabolism and ULK1/ATG13-mediated autophagy: overcome by pH/ROS-responsive PPD/PDP@si-FDX1 nanomicelles [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Ovarian cancer (OC) is often characterized by poor prognosis due to paclitaxel (TAX) resistance, with ferredoxin 1 (FDX1) emerging as a key mediator of copper metabolism.
Yangmei Gong, Zhizhi Deng, Jie Wu, Yi Hu
doaj +2 more sources
Frontiers in Immunology, 2022 BackgroundCuproptosis, a newly discovered form of cell death, is regulated by protein lipoylation and is related to mitochondrial metabolism. However, further research is needed to determine how the cuproptosis-related gene ferredoxin 1 (FDX1) affects ...
Tao Wang +5 more
exaly +3 more sources
Frontiers in Immunology, 2022 BackgroundThe mechanism of copper-induced cellular death was newly discovered and termed cuproptosis. Inducing cuproptosis in cancer cells is well anticipated for its curative potential in treating tumor diseases.
Zhengang Hu, Quan Cheng
exaly +3 more sources
Frontiers in Genetics, 2022 Background: The latest research identified cuproptosis as an entirely new mechanism of cell death. However, as a key regulator in copper-induced cell death, the prognostic and immunotherapeutic value of FDX1 in pan-cancer remains unclear.Methods: Data ...
Chi Zhang +7 more
exaly +3 more sources
AT-101 inhibits the proliferation and invasion of tongue squamous carcinoma cells by targeting the miR-21-5p/FDX1 axis [PDF]
Scientific ReportsTongue squamous cell carcinoma (TSCC) is an aggressive oral malignancy with an increasing incidence worldwide, however, the molecular regulatory mechanisms underlying its progression still unclear.
Shuai Fu +4 more
doaj +2 more sources
Emodin triggers cuproptosis to suppress hepatocellular carcinoma via SLC7A11/FDX1 axis [PDF]
Frontiers in OncologyBackgroundHepatocellular carcinoma (HCC) is a lethal malignancy with limited therapeutic options, necessitating novel treatment strategies. This study investigates the potential of emodin, a natural anthraquinone, to suppress HCC by inducing cuproptosis,
Yantong Chen +6 more
doaj +2 more sources
Cells, 2023 Background: Progress in the diagnosis and treatment of clear cell renal cell carcinoma (ccRCC) has significantly prolonged patient survival. However, ccRCC displays an extreme heterogenous characteristic and metastatic tendency, which limit the benefit ...
Aimin Jiang, Baohua Zhu, Juan Lu
exaly +3 more sources