Results 1 to 10 of about 2,875 (127)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer [PDF]

Advanced Science
Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear.
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
doaj   +3 more sources

FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis

Heliyon, 2023
Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development.
Gaoxiang Chen, Jianan Zhang, Weifeng Teng, Yong Luo, Xiaochun Ji   +4 more
exaly   +3 more sources

SF1 regulates the transcription of FDX1 to promote cuproptosis in pediatric sepsis-related acute lung injury by interacting with cJUN [PDF]

Biology Direct
Background Pediatric sepsis, a major cause of acute lung injury (ALI), involves a dysregulated host response. Cuproptosis is a novel copper-dependent cell death process regulated by Ferredoxin 1 (FDX1).
Yanrong Wang, Junhua Sun, Lifen Zhang, Shenghu Zhou, Fang Zhao   +4 more
doaj   +2 more sources

Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma

Frontiers in Immunology, 2022
BackgroundThe mechanism of copper-induced cellular death was newly discovered and termed cuproptosis. Inducing cuproptosis in cancer cells is well anticipated for its curative potential in treating tumor diseases.
Quan Cheng, Zhengang Hu
exaly   +3 more sources

Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker

Frontiers in Genetics, 2022
Background: The latest research identified cuproptosis as an entirely new mechanism of cell death. However, as a key regulator in copper-induced cell death, the prognostic and immunotherapeutic value of FDX1 in pan-cancer remains unclear.Methods: Data ...
Chi Zhang, Yuanxiao Zeng, Xiuchen Guo, Hangjing Shen, Jianhao Zhang, Kaikai Wang, Mengmeng Ji, Shengwei Huang   +7 more
exaly   +3 more sources

FDX1 Depletion Activates CD8⁺ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer. [PDF]

Cancer Sci
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Wu J, Lian Z, Li M, Qin X, Lei X, Yang L, Bing L, Li Q, Zhou L, Ma Z, Xu X, Huang J, Chen Z, Chen L, Zhang L, Xiao Z, Jian X, Zhang X, Ding Y, Ye Y, Liang L, Jiao H, Wang S.   +22 more
europepmc   +2 more sources

SOX2 Inhibits Cuproptosis to Affect Cisplatin Resistance in Non-Small Cell Lung Cancer by Activating the Wnt/ATP7B Signaling Pathway. [PDF]

Kaohsiung J Med Sci
ABSTRACT Cisplatin (CDDP) resistance constitutes the principal clinical challenge in the treatment of advanced non‐small cell lung cancers (NSCLC). Disturbances in copper metabolism are closely linked with tumor drug resistance. SOX2, a pivotal stemness transcription factor (TF), holds an important role in chemotherapy resistance.
Chen K, He FM, Huang YH, Fang T, Zheng YP, Cai JF.   +5 more
europepmc   +2 more sources

Cuproptosis-related gene FDX1 expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma

Frontiers in Immunology, 2022
BackgroundCuproptosis, a newly discovered form of cell death, is regulated by protein lipoylation and is related to mitochondrial metabolism. However, further research is needed to determine how the cuproptosis-related gene ferredoxin 1 (FDX1) affects ...
Tao Wang, Yufeng Liu, Qing Li, Yang Luo, Dawei Liu, Bin Li   +5 more
exaly   +3 more sources

Ferrodoxin 1 (FDX1) drives paclitaxel resistance in ovarian cancer via copper metabolism and ULK1/ATG13-mediated autophagy: overcome by pH/ROS-responsive PPD/PDP@si-FDX1 nanomicelles [PDF]

Journal of Experimental & Clinical Cancer Research
Background Ovarian cancer (OC) is often characterized by poor prognosis due to paclitaxel (TAX) resistance, with ferredoxin 1 (FDX1) emerging as a key mediator of copper metabolism.
Yangmei Gong, Zhizhi Deng, Jie Wu, Yi Hu
doaj   +2 more sources

Astrocytic FDX1 Contributes to Copper Dyshomeostasis-associated Synaptic Dysfunction in Depression and Is Modulated by Exercise. [PDF]

Adv Sci (Weinh)
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Gao L, Hui R, Tang Z, Feng T, Hu Z, Zhang X, Jiang P, Zhao H, So KF, Luo T, Chang Y, Yan L.   +11 more
europepmc   +2 more sources