Results 21 to 30 of about 3,265 (192)
Pharmacogenomics and Personalized Medicine, 2022 Yuhui Yun,1,* Yun Wang,2,* Ende Yang,1 Xin Jing1 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Medical Oncology, Tangdu Hospital, The ...
Yun Y, Wang Y, Yang E, Jing X
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Cuproptosis-related gene FDX1 as a prognostic biomarker for kidney renal clear cell carcinoma correlates with immune checkpoints and immune cell infiltration [PDF]
Frontiers in Genetics, 2023 Background: Kidney renal clear cell carcinoma (KIRC) is not sensitive to radiotherapy and chemotherapy, and only some KIRC patients can benefit from immunotherapy and targeted therapy.
Yimin Yao +3 more
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Cells, 2022 As a newly identified type of programmed cell death, cuproptosis may have an impact on cancer development, including clear cell renal cell carcinoma (ccRCC).
Mingyue Xie +8 more
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NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance [PDF]
Cancer CommunicationsBackground: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking.
Weikai Wang +15 more
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FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma [PDF]
Frontiers in Pharmacology, 2021 Background: Lung cancer has emerged as one of the most common cancers in recent years. The mitochondrial electron transport chain (ETC) is closely connected with metabolic pathways and inflammatory response. However, the influence of ETC-associated genes
Zeyu Zhang +6 more
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FDX1 regulates leydig cell ferroptosis mediates PM2.5-induced testicular dysfunction of mice
Ecotoxicology and Environmental Safety, 2023 Epidemiological studies have established an association between chronic exposure to PM2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this study, we established mice models exposed to PM2.5 for 16 weeks, and a significant decrease in sperm quality accompanied by an increase in testosterone levels were observed ...
Lipeng Li +11 more
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Role of ferredoxin 1 (FDX1) in cancer and its therapeutic potential
Cancer Pathogenesis and TherapyFerredoxin 1 (FDX1) is a small iron-sulfur (Fe–S) cluster protein localized to the mitochondria. It functions as an electron carrier in diverse metabolic pathways and is critically involved in the regulation of protein lipoylation Accumulating evidence ...
Fen He +7 more
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Modulating ovarian cancer progression through FDX1-driven autophagy
npj Precision OncologyFerredoxin 1 (FDX1) emerges as a crucial regulator of autophagy and copper metabolism in ovarian cancer (OC), as revealed by this investigation. Predominantly localized to the cytoplasm and mitochondria, FDX1 coordinates autophagic activity by modulating
Chang Liu +4 more
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MedComm – Oncology, Volume 5, Issue 3, September 2026.This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao +10 more
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BMC CancerBackground Cuprotosis has been identified as a novel way of cell death. The key regulator ferredoxin 1 (FDX1) was explored via pan-cancer analysis, and its prediction models were proposed across seven malignancies and two imaging modalities.
Qiuyuan Yue +6 more
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