Results 21 to 30 of about 2,610 (155)

A novel prognostic signature of cuproptosis-related genes and the prognostic value of FDX1 in gliomas

Frontiers in Genetics, 2022
Background: Gliomas are the most common malignant tumors of the central nervous system, with extremely bad prognoses. Cuproptosis is a novel form of regulated cell death. The impact of cuproptosis-related genes on glioma development has not been reported.
HuaXin Zhu, HuaXin Zhu, Qinsi Wan, Jiacong Tan, Jiacong Tan, Hengyang Ouyang, Xinyi Pan, MeiHua Li, YeYu Zhao   +8 more
doaj   +3 more sources

Ferredoxins: master regulators in mitochondrial redox homeostasis and programmed cell death [PDF]

Redox Biology
Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe–S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe–S cluster biogenesis, and ...
Yajuan Lu, Yunyi Wu, Chen Yang, Yi Zhou, Xueying Ren, Haoran Li, Hangqi Huang, Feifan Pan, Aoli Deng, Yi Lu, Jiayi Yang, Xiangmin Tong, Yanchun Li, Jing Du   +13 more
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lncRNA RP11-199F11.2 promotes high-grade serous ovarian cancer cell proliferation by regulating cuproptosis through FDX1 [PDF]

Scientific Reports
To elucidate the expression characteristics of the long noncoding RNA RP11-199F11.2 (RP11) in high-grade serous ovarian cancer (HGSOC) and its potential mechanism of regulating cancer progression via the copper-death pathway, and to evaluate the ...
Shishi Xu, Linping Wang, Yingying Wu, Yufang Xia, Lingzhi Wang, Xiao Yu, Xin Sun, Yanhui Lou   +7 more
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AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science
Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly in breast cancer. This study demonstrates that triple‐negative breast cancer (TNBC) bears a relatively elevated copper levels
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
doaj   +3 more sources

Pan-cancer integrated bioinformatics analysis reveals cuproptosis related gene FDX1 is a potential prognostic and immunotherapeutic biomarker for lower-grade gliomas

Frontiers in Molecular Biosciences, 2023
FDX1 participates in cuproptosis, a copper-dependent cell death mode, which might influence tumor progressions like ferroptosis and pyroptosis. However, the role of FDX1 in tumors remains to be explored.
Wei Huang, Yuliang Wu, Yuliang Wu, Jihui Zhu, Ning Luo, Chunyan Wang, Shupeng Liu, Zhongping Cheng   +7 more
doaj   +1 more source

Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2

Nature Chemical Biology, 2022
Ferredoxins comprise a large family of iron-sulfur (Fe-S) proteins that shuttle electrons in diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe-S protein biogenesis.
Vinzent Schulz, Somsuvro Basu, Sven-A. Freibert, Holger Webert, Linda Boss, Ulrich Mühlenhoff, Fabien Pierrel, Lars-O. Essen, Douglas M. Warui, Squire J. Booker, Oliver Stehling, Roland Lill   +11 more
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Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer

Frontiers in Genetics, 2022
Background: Cuproptosis is a recently discovered form of programmed cell death. Ferredoxin 1 (FDX1) is a key gene that mediates this process. However, the role of FDX1 in human tumors is not clear.Methods: We comprehensively analyzed the differential ...
Xiang Li, Zihan Dai, Jincheng Liu, Zhenqian Sun, Na Li, Guangjun Jiao, Hongxin Cao   +6 more
doaj   +1 more source

The FDX1 methylation regulatory mechanism in the malignant phenotype of glioma

Genomics, 2023
To explore FDX1 methylation as a regulatory mechanism in the malignant phenotype of glioma, we screened for pathways involved through bioinformatic analysis, then proceeded with RIP and cell models to verify the regulation of RNAs and mitophagy. We chose Clone and Transwell assays to evaluate the malignant phenotype of glioma cells. MMP was detected by
Li, Guowei, Lu, Xiufang, Xu, Qianqian, Jin, Yanping   +3 more
openaire   +2 more sources

Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis

Frontiers in Pharmacology, 2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is the key regulator in copper-dependent cell death.
Longfei Yang, Longfei Yang, Yuwei Zhang, Yuwei Zhang, Yang Wang, Peng Jiang, Fengping Liu, Ninghan Feng, Ninghan Feng   +8 more
doaj   +1 more source

FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis

Frontiers in Genetics, 2022
Ferredoxin 1 (FDX1), an iron-sulphur protein, is responsible for electron transfer in a range of metabolic redox reactions. Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer characterised by metabolic reprogramming, and FDX1 is a critical ...
Xing Huang, Xing Huang, Tao Wang, Tao Wang, Jiali Ye, Jiali Ye, Huayi Feng, Huayi Feng, Xiangyi Zhang, Xiangyi Zhang, Xin Ma, Baojun Wang, Yan Huang, Xu Zhang   +13 more
doaj   +1 more source