Results 1 to 10 of about 332,900 (265)

Immunotherapy: Reshape the Tumor Immune Microenvironment

Frontiers in Immunology, 2022
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can
Bingzhe LV, Bingzhe LV, Yunpeng Wang, Yunpeng Wang, Dongjiang Ma, Dongjiang Ma, Wei Cheng, Wei Cheng, Jie Liu, Jie Liu, Tao Yong, Tao Yong, Hao Chen, Hao Chen, Chen Wang, Chen Wang   +15 more
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Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

Signal Transduction and Targeted Therapy, 2021
Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anti-cancer ...
Tianyu Tang, Xing Huang, Gang Zhang, Zhengtao Hong, Xueli Bai, Tingbo Liang   +5 more
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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
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A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women

Frontiers in Oncology, 2022
BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao, Xuan Shao, Xiaoyan Jin, Xiaoyan Jin, Xiaoyan Jin, Zhigang Chen, Zhigang Chen, Zhigang Zhang, Zhigang Zhang, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Zhen Wang, Zhen Wang, Ying Cui, Wan-Hung Fan, Ke Wang, Ke Wang, Xiuyan Yu, Xiuyan Yu, Jian Huang, Jian Huang   +22 more
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Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy

Frontiers in Pharmacology, 2021
Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal
Jianming Hu, Jianming Hu, Leyi Zhang, Leyi Zhang, Wuzhen Chen, Wuzhen Chen, Lesang Shen, Lesang Shen, Jingxin Jiang, Jingxin Jiang, Shanshan Sun, Shanshan Sun, Zhigang Chen, Zhigang Chen   +13 more
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Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature

Frontiers in Immunology, 2023
IntroductionLipid metabolic reprogramming is gaining attention as a hallmark of cancers. Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is closely related to lipid metabolism.
Lesang Shen, Lesang Shen, Lesang Shen, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Yao Yao, Yao Yao, Yao Yao, Jianming Hu, Jianming Hu, Jianming Hu, Jun Zhou, Fengbo Huang, Chao Ni, Chao Ni, Chao Ni   +22 more
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“γδT Cell-IL17A-Neutrophil” Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy

Frontiers in Immunology, 2021
Angiogenesis is an essential physiological process and hallmark of cancer. Currently, antiangiogenic therapy, mostly targeting the vascular endothelial growth factor (VEGF)/VEGFR2 signaling axis, is commonly used in the clinic for solid tumors.
Zhigang Zhang, Zhigang Zhang, Chenghui Yang, Lili Li, Lili Li, Ying Zhu, Ke Su, Lingyun Zhai, Zhen Wang, Zhen Wang, Jian Huang, Jian Huang, Jian Huang   +12 more
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Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Biomarker Research, 2021
Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen   +7 more
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CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
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Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Signal Transduction and Targeted Therapy, 2023
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery.
Siyu Guo, Yihan Yao, Yang Tang, Zengfeng Xin, Dang Wu, Chao Ni, Jian Huang, Qichun Wei, Ting Zhang   +8 more
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