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Development of Immunotherapy Strategies Targeting Tumor Microenvironment Is Fiercely Ongoing

Frontiers in Immunology, 2022
Tumor immune microenvironment is a very complex system that is influenced by a wide range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines can interact with tumor cells and jointly regulate this complex ecosystem ...
Rilan Bai, Jiuwei Cui
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Immune suppressive mechanisms in the tumor microenvironment [PDF]

Current Opinion in Immunology, 2016
Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells.
Munn, David H, Bronte, Vincenzo
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Fractionated Radiation Therapy for Large and Giant Cavernous Sinus Hemangioma: A Retrospective Study

Frontiers in Neurology, 2020
Purpose: Surgical resection has been traditionally used as a treatment for cavernous sinus hemangioma (CSH). However, this is usually difficult due to tumor vascularity and results in complications especially in large and giant CSH (volume >20 cm3 ...
Zengfeng Xin, Zengfeng Xin, Yihan Yao, Guodi Chen, Liancong Wang, Meibao Shu, Qinghua Lv, Haifeng Yu, Ting Zhang, Ting Zhang   +9 more
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The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

Journal of Experimental & Clinical Cancer Research, 2021
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies have claimed that microbes reside within tumor cells and immune cells, suggesting that these microbes can ...
Jiayao Ma, Lingjuan Huang, Die Hu, Shan Zeng, Ying Han, Hong Shen   +5 more
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Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions

Frontiers in Cell and Developmental Biology, 2020
Tuft cells, rare solitary chemosensory cells, are distributed in mucosal epithelium throughout mammalian organs. Their nomenclatures are various in different organs and may be confused with other similar cells.
Jun Pan, Jun Pan, Jun Pan, Leyi Zhang, Leyi Zhang, Leyi Zhang, Xuan Shao, Xuan Shao, Jian Huang, Jian Huang, Jian Huang   +10 more
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Characterization of the Neuroendocrine Tumor Immune Microenvironment [PDF]

Pancreas, 2018
Objectives The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs.
Annacarolina, da Silva, Michaela, Bowden, Sui, Zhang, Yohei, Masugi, Aaron R, Thorner, Zachary T, Herbert, Chensheng Willa, Zhou, Lauren, Brais, Jennifer A, Chan, F Stephen, Hodi, Scott, Rodig, Shuji, Ogino, Matthew H, Kulke   +12 more
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Peripheral inflammatory T cell subsets are effective predictive factors in the development of heterotopic ossification after posttraumatic elbow surgery

Heliyon
Heterotopic ossification refers to the pathological formation of extra-skeletal bone. It is a common complication of trauma or surgery that can cause disability and has no definitive cure.
Zengfeng Xin, Junhua Chen, Fengbo Huang, Siyu Guo, Yihan Yao, Yang Tang, Hang Li, Qinghua Lv, Ting Zhang   +8 more
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Immunometabolism in the tumor microenvironment and its related research progress

Frontiers in Oncology, 2022
The tumor immune microenvironment has been a research hot spot in recent years. The cytokines and metabolites in the microenvironment can promote the occurrence and development of tumor in various ways and help tumor cells get rid of the surveillance of ...
Ziheng Zhang, Yajun Hu, Yuefeng Chen, Zhuoneng Chen, Yexin Zhu, Mingmin Chen, Jichu Xia, Yixuan Sun, Wenfang Xu   +8 more
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Immune aspects of the breast tumor microenvironment [PDF]

Breast Cancer Management, 2013
The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other.
Akhil, Chawla, Gheath, Alatrash, Yun, Wu, Elizabeth A, Mittendorf   +3 more
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Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Journal of Nanobiotechnology
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies.
Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu   +17 more
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